INT32706

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1988
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 51
Total Number 53
Disease Relevance 19.48
Pain Relevance 15.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cyp3a23/3a1) endoplasmic reticulum (Cyp3a23/3a1)
Anatomy Link Frequency
bladder 4
liver 2
femur 2
Kupffer cell 2
fat 2
Cyp3a23/3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 1632 100.00 Very High Very High Very High
Nerve growth factor 237 100.00 Very High Very High Very High
Central nervous system 15 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
amygdala 6 99.98 Very High Very High Very High
opiate 1 99.58 Very High Very High Very High
fluoxetine 6 99.44 Very High Very High Very High
halothane 12 98.96 Very High Very High Very High
Inflammation 469 98.60 Very High Very High Very High
chemokine 95 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cystitis 100 100.00 Very High Very High Very High
Injury 55 99.98 Very High Very High Very High
Infection 135 99.84 Very High Very High Very High
Rheumatoid Arthritis 619 99.76 Very High Very High Very High
Arthritis 568 98.60 Very High Very High Very High
Osteoporosis 99 98.48 Very High Very High Very High
Hyperlipidemia 64 98.42 Very High Very High Very High
Toxicity 71 98.40 Very High Very High Very High
INFLAMMATION 461 98.20 Very High Very High Very High
Adverse Drug Reaction 42 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, Northern blot analysis showed that CYP1A2, CYP2E1, CYP2C11, and CYP3A1/2 mRNAs decreased in the state of PCM as well.
Gene_expression (decreased) of CYP3A1
1) Confidence 0.65 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15356995 Disease Relevance 0.28 Pain Relevance 0
For the in vitro release study, another batch of P-Dex was synthesized with the Dex content determined to be 106 mg/g polymer conjugate by the TNBS assay and by HPLC after full hydrolysis.
Gene_expression (synthesized) of Dex associated with dexamethasone
2) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0 Pain Relevance 0.58
For the in vitro release study, another batch of P-Dex was synthesized with the Dex content determined to be 106 mg/g polymer conjugate by the TNBS assay and by HPLC after full hydrolysis.
Gene_expression (synthesized) of Dex associated with dexamethasone
3) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0 Pain Relevance 0.58
Synthesis of Dex-containing monomer and its copolymerization with HPMA may resolve the issue.
Gene_expression (Synthesis) of Dex-containing associated with dexamethasone
4) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.18 Pain Relevance 0.52
P-Dex was synthesized with the following exemplary procedure (Figure 1).
Gene_expression (synthesized) of Dex associated with dexamethasone
5) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0 Pain Relevance 0.10
Synthesis of P-Dex
Gene_expression (Synthesis) of Dex associated with dexamethasone
6) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0 Pain Relevance 0.10
KEY FINDINGS: The expression of several drug metabolising enzymes was modulated by oxycodone treatment: cytochrome P450 (CYP) 2B2, CYP2C13, CYP17A1, epoxide hydrolase 2, carboxylesterase 2, flavin-containing monooxygenase 1, glutathione S-transferase alpha 5 (rGSTA5) and CYP3A2.
Gene_expression (expression) of CYP
7) Confidence 0.58 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20487198 Disease Relevance 0 Pain Relevance 0
However, the synthesis and especially the purification of the Dex-containing monomer may continue to be difficult.
Gene_expression (synthesis) of Dex-containing associated with dexamethasone
8) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.17 Pain Relevance 0.56
These differences were not as apparent, however, in the lumbar vertebra and the femur, where both the P-Dex and Dex groups had a greater BMD than the untreated group, but the values were not significantly different from each other.
Gene_expression (groups) of Dex in femur associated with dexamethasone
9) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 1.01 Pain Relevance 0.81
These differences were not as apparent, however, in the lumbar vertebra and the femur, where both the P-Dex and Dex groups had a greater BMD than the untreated group, but the values were not significantly different from each other.
Gene_expression (groups) of Dex in femur associated with dexamethasone
10) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 1.01 Pain Relevance 0.81
MI complexation of CYP appeared to contribute significantly to inhibition by FLU, as evidenced by the 21% decrease in apparent microsomal CYP content produced by 50 microM FLU in the presence of NADPH. 3.
Gene_expression (produced) of CYP associated with fluoxetine
11) Confidence 0.51 Published 2003 Journal Xenobiotica Section Abstract Doc Link 14555335 Disease Relevance 0 Pain Relevance 0.69
A novel HPMA copolymer-Dex conjugate was designed, synthesized, and tested in an animal model of inflammatory arthritis.
Gene_expression (synthesized) of copolymer-Dex associated with inflammation, dexamethasone and arthritis
12) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.57 Pain Relevance 0.53
We previously found that DU chronic exposure induces the expression of CYP enzymes involved in the metabolism of xenobiotics (drugs).
Gene_expression (expression) of CYP
13) Confidence 0.50 Published 2007 Journal Toxicology Section Abstract Doc Link 17126469 Disease Relevance 0.21 Pain Relevance 0.24
At 72 h of FFx, liver tissues were isolated to determine the mRNA and protein expression of CYP isozymes and NADPH-P450 reductase by reverse transcription-polymerase chain reaction and Western immunoblotting, respectively.
Spec (determine) Gene_expression (expression) of CYP in liver
14) Confidence 0.48 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.51 Pain Relevance 0.09
The aim of this study was to investigate the effect of trauma on cytochrome P450 (CYP) gene expression and to determine the role of Kupffer cells in trauma-induced alteration of CYP isozymes.
Gene_expression (expression) of CYP in Kupffer cells associated with injury
15) Confidence 0.48 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.47 Pain Relevance 0.09
Our findings suggest that FFx differentially regulates the expression of CYP isozyme through Kupffer cell-independent mechanisms.
Gene_expression (expression) of CYP isozyme in Kupffer cell
16) Confidence 0.48 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.27 Pain Relevance 0.05
The catechol was formed at rates of 2.21 and 0.53 nmol/nmol of P-450/10 min by cytochromes P-450PB-B and P-450 beta NF-B, respectively.
Gene_expression (formed) of P-450 beta
17) Confidence 0.39 Published 1988 Journal Chem. Res. Toxicol. Section Abstract Doc Link 2979711 Disease Relevance 0.08 Pain Relevance 0.56
In the present study, we examined the metabolism of MTEP in liver microsomes and expressed rat and human CYP isoforms.
Gene_expression (expressed) of CYP in liver
18) Confidence 0.38 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16153770 Disease Relevance 0.08 Pain Relevance 0.24
Moreover, in the kidney, CYP2E1 gene expression, an important CYP responsible for APAP bioactivation and toxicity, is increased (p<0.01) in the DU-exposed group compared to the control group.
Gene_expression (expression) of CYP in kidney associated with toxicity
19) Confidence 0.34 Published 2007 Journal Toxicology Section Abstract Doc Link 17126469 Disease Relevance 0.53 Pain Relevance 0.22
Incubation of MTEP with expressed rat and human CYP isoforms showed that CYP1A and CYP2C isoforms are primarily responsible for the metabolism of this compound.
Gene_expression (expressed) of CYP
20) Confidence 0.33 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16153770 Disease Relevance 0.07 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox