INT32709

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Context Info
Confidence 0.54
First Reported 1988
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 18.27
Pain Relevance 6.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Hbb)
Anatomy Link Frequency
blood 6
platelet 2
red blood cell 2
liver 1
erythrocyte 1
Hbb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 152 99.72 Very High Very High Very High
diclofenac 8 99.50 Very High Very High Very High
anesthesia 44 99.10 Very High Very High Very High
withdrawal 30 99.08 Very High Very High Very High
antagonist 12 98.84 Very High Very High Very High
Thermal hyperalgesia 7 98.20 Very High Very High Very High
imagery 197 97.64 Very High Very High Very High
fibrosis 10 97.44 Very High Very High Very High
intrathecal 5 97.42 Very High Very High Very High
isoflurane 12 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anaemia 55 99.84 Very High Very High Very High
Diabetes Mellitus 246 99.76 Very High Very High Very High
Pressure Volume 2 Under Development 59 99.76 Very High Very High Very High
Cv General 3 Under Development 27 99.72 Very High Very High Very High
Hemorrhage 116 99.24 Very High Very High Very High
Chronic Renal Failure 62 99.12 Very High Very High Very High
Body Weight 62 99.02 Very High Very High Very High
Nociception 5 98.76 Very High Very High Very High
Hyperalgesia 12 98.20 Very High Very High Very High
Congenital Anomalies 21 97.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ni-implanted rats showed a significant decrease in red blood cells, hemoglobin, and hematocrit at the time of morbidity, indicating possible Ni-induced anemia.
Negative_regulation (decrease) of hemoglobin in red blood cells associated with anaemia
1) Confidence 0.54 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257598 Disease Relevance 0.65 Pain Relevance 0
Rats implanted with 20 WA pellets exhibited significant increases in white blood cell counts, red blood cell counts, hemoglobin, and hematocrit levels compared with Ta control rats, whereas rats implanted with 20 Ni pellets had significant decreases in red blood cell counts, hemoglobin, and hematocrit levels (Table 1).
Negative_regulation (decreases) of hemoglobin in red blood cell
2) Confidence 0.54 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257598 Disease Relevance 0.39 Pain Relevance 0
The results suggest that total lack of iron producing a moderate decrease of blood hemoglobin concentration creates a significant risk in abdominal surgery and focus the activation of the anaerobic energy yielding process.
Negative_regulation (decrease) of hemoglobin in blood
3) Confidence 0.51 Published 1988 Journal In Vivo Section Abstract Doc Link 2979860 Disease Relevance 0.15 Pain Relevance 0.08
Total depletion of iron stores with a moderately decreased blood hemoglobin concentration (114 x 10 vs. 155 x 12 g/l in controls, n = 28) was produced in rats (n = 28) by rearing them for six weeks on an iron free diet, in iron free cages, starting at two weeks of age.
Negative_regulation (decreased) of hemoglobin in blood
4) Confidence 0.51 Published 1988 Journal In Vivo Section Abstract Doc Link 2979860 Disease Relevance 0.15 Pain Relevance 0.07
Hemoglobin oxygen saturation was decreased minimally, and the incidences of catalepsy and corneal-reflex loss were minimal, even at large doses of DTC401.
Negative_regulation (decreased) of Hemoglobin
5) Confidence 0.47 Published 1996 Journal Anesthesiology Section Body Doc Link 8712449 Disease Relevance 0 Pain Relevance 0
The anoxia-induced increase in frequency is reduced when experiments are performed in the presence of the competitive nitric oxide (NO)-synthase inhibitors N(G)-nitro-L-arginine methyl ester and N(G)-nitro-L-arginine, as well as reduced hemoglobin.
Negative_regulation (reduced) of hemoglobin associated with hypoxia
6) Confidence 0.39 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9197285 Disease Relevance 0.42 Pain Relevance 0.32
In contrast, the larger doses of morphine sulfate significantly decreased hemoglobin oxygen saturation, and caused catalepsy and loss of the corneal-reflex.
Negative_regulation (decreased) of hemoglobin
7) Confidence 0.34 Published 1996 Journal Anesthesiology Section Body Doc Link 8712449 Disease Relevance 0 Pain Relevance 0
Elevating intracranial pressure reverses the decrease in deoxygenated hemoglobin and abolishes the post-stimulus overshoot upon somatosensory activation in rats.
Negative_regulation (decrease) of hemoglobin associated with anesthesia and cva
8) Confidence 0.25 Published 2010 Journal Neuroimage Section Title Doc Link 20420930 Disease Relevance 0.66 Pain Relevance 0.46
BOLD fMRI localizes activated brain areas by measuring decreases of deoxygenated hemoglobin (deoxy-Hb) caused by neurovascular coupling.
Negative_regulation (decreases) of hemoglobin in brain
9) Confidence 0.22 Published 2010 Journal Neuroimage Section Abstract Doc Link 20420930 Disease Relevance 0.41 Pain Relevance 0.23
Hemoglobin concentration was significantly reduced when blood loss volume reached 12% or more of ETBV in both groups of rats; however, there were no significant differences.


Negative_regulation (reduced) of Hemoglobin in blood associated with pressure volume 2 under development
10) Confidence 0.21 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004820 Disease Relevance 0.39 Pain Relevance 0.08
Acetylcholine-induced relaxation also was antagonized by an inhibitor of nitric oxide synthase (N-methyl-L-arginine), a nitric oxide scavenger (hemoglobin) and an inhibitor of guanylate cyclase (methylene blue).
Negative_regulation (inhibitor) of hemoglobin
11) Confidence 0.17 Published 1996 Journal Anesthesiology Section Body Doc Link 8694354 Disease Relevance 0 Pain Relevance 0
Posttreatment with the competitive substrate inhibitor of nitric oxide synthase, N omega-nitro-L-arginine or with hemoglobin, which binds NO extracellularly, inhibited this postexcitotoxic increase in MK-801 binding.
Negative_regulation (inhibitor) of hemoglobin
12) Confidence 0.16 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953729 Disease Relevance 0 Pain Relevance 0.24
In both groups of rats, hemoglobin concentrations were significantly reduced after the third blood withdrawal and dextran treatment as compared with the baseline values.
Negative_regulation (reduced) of hemoglobin in blood associated with withdrawal
13) Confidence 0.15 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004820 Disease Relevance 0.27 Pain Relevance 0.10
Partial treatment of diabetes, as indicated by decreased glycated hemoglobin (GHb) compared to untreated diabetic rats, was associated with an isoflurane MED of 1.05 vol%, intermediate between a control mean of 1.57 vol% and an untreated diabetic mean of 0.82 vol% (p < 0.01), with a trend toward normalization of both PMCA and PLMT I activity.
Negative_regulation (decreased) of glycated hemoglobin associated with diabetes mellitus and isoflurane
14) Confidence 0.12 Published 1995 Journal Life Sci. Section Abstract Doc Link 7752806 Disease Relevance 0.80 Pain Relevance 0.24
The oxygen distribution in a Krogh cylinder was computed assuming a linear decrease of hemoglobin saturation from the arterial to the venous end of the capillary.
Negative_regulation (decrease) of hemoglobin in capillary
15) Confidence 0.11 Published 2005 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 16594142 Disease Relevance 0 Pain Relevance 0
The effects of intrathecal injection of MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist, N-nitro-L-arginine methyl ester (L-NAME), a NO synthase inhibitor, methylene blue (MB), a soluble guanylate cyclase inhibitor, and hemoglobin (Hb), a NO scavenger, on the development of thermal hyperalgesia after the sciatic nerve ligature were examined in the presence and absence of 1 and 10 microg of NOC-18.
Neg (NO) Negative_regulation (inhibitor) of hemoglobin in sciatic nerve associated with thermal hyperalgesia, antagonist, sciatic nerve and intrathecal
16) Confidence 0.11 Published 1998 Journal Brain Res. Section Abstract Doc Link 9593928 Disease Relevance 1.10 Pain Relevance 1.10
Animals treated with the alcoholic extract of leaves of B. prionitis Linn showed a significant decrease in blood glucose level (P<0.01) and glycosylated hemoglobin (P<0.01).
Negative_regulation (decrease) of hemoglobin in blood
17) Confidence 0.08 Published 2010 Journal Indian Journal of Pharmacology Section Abstract Doc Link PMC2907017 Disease Relevance 0.50 Pain Relevance 0
The alcoholic leaf extract significantly decreased (P<0.01) the glycosylated hemoglobin level, but a moderate and non-significant decrease was seen with alcoholic root extract [Table 1].


Negative_regulation (decreased) of hemoglobin in leaf
18) Confidence 0.08 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2907017 Disease Relevance 0.58 Pain Relevance 0
The effects of intrathecal injection of N-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor; methylene blue (MB), a soluble guanylate cyclase inhibitor and hemoglobin (Hb), an NO scavenger, on the nociceptive threshold were measured in the presence and absence of 0.1, 1 and 10 microg of NOC-18.
Negative_regulation (inhibitor) of hemoglobin associated with nociception and intrathecal
19) Confidence 0.08 Published 1997 Journal J. Neurol. Sci. Section Abstract Doc Link 9455970 Disease Relevance 0.42 Pain Relevance 0.34
In the short-term high dose study, paclitaxel treated rats lost 10% of their body weight, had reduced erythrocyte counts, hematocrit and hemoglobin concentrations which were not prevented by treatment with prosaptide.
Negative_regulation (prevented) of hemoglobin in erythrocyte associated with body weight
20) Confidence 0.08 Published 1998 Journal Neurotoxicology Section Abstract Doc Link 9553960 Disease Relevance 0.45 Pain Relevance 0.22

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