INT327104

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PIM1) plasma membrane (PIM1) nucleus (PIM1)
cell cycle (PIM1) transcription factor binding (PIM1) cytoplasm (PIM1)
PIM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 95.36 Very High Very High Very High
Hyperplasia 1 53.60 Quite High
Cancer 25 51.64 Quite High
Adenocarcinoma 1 13.36 Low Low
Disease 29 6.92 Low Low
Papillomavirus Infection 21 5.00 Very Low Very Low Very Low
Metastasis 12 5.00 Very Low Very Low Very Low
Toxicity 10 5.00 Very Low Very Low Very Low
Exanthema 8 5.00 Very Low Very Low Very Low
Hypomagnesemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Processes that are activated by EGFR stimulation include signal transduction pathways for PI3K-Akt (related to survival and apoptosis evasion) and Ras-Raf-MEK-MAPK (relating to proliferation).15 In addition, there is an interaction between EGFR expression and signal transducers and activators of transcription 3 (eg, STAT3), which play a role in the regulation of transcription of genes involved in cell cycle progression such as Fos, Cyclin-D, CDC25A, c-Myc and Pim1 and the upregulation of antiapoptotic genes such as BCL2.16,17
Transcription (transcription) of Pim1 associated with apoptosis
1) Confidence 0.13 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921255 Disease Relevance 0.29 Pain Relevance 0

General Comments

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