INT327105

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.28 Pain Relevance 0

signal transduction (CCND3) nucleus (CCND3) cell division (CCND3) cytoplasm (CCND3)

CCND3 (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 2 5.00 palliative 1 5.00 methotrexate 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 2 95.36 Hyperplasia 1 51.68 Cancer 25 51.64 Adenocarcinoma 1 11.44 Disease 29 6.92 Papillomavirus Infection 21 5.00 Metastasis 12 5.00 Toxicity 10 5.00 Exanthema 8 5.00 Hypomagnesemia 6 5.00

Sentences Mentioned In

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Negation

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Processes that are activated by EGFR stimulation include signal transduction pathways for PI3K-Akt (related to survival and apoptosis evasion) and Ras-Raf-MEK-MAPK (relating to proliferation).15 In addition, there is an interaction between EGFR expression and signal transducers and activators of transcription 3 (eg, STAT3), which play a role in the regulation of transcription of genes involved in cell cycle progression such as Fos, Cyclin-D, CDC25A, c-Myc and Pim1 and the upregulation of antiapoptotic genes such as BCL2.16,17

Transcription (transcription) of Cyclin-D associated with apoptosis

1) Confidence 0.04 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921255 Disease Relevance 0.28 Pain Relevance 0

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