INT327116

Context Info Confidence 0.22 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.69 Pain Relevance 0.55

nucleus (AES)

Anatomy Link Frequency blood 4 AES (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 6 100.00 headache 8 95.04 pruritus 1 69.20 Bile 34 60.60 agonist 5 46.12 Osteoarthritis 1 39.44 spinal stenosis 1 36.64 Potency 23 16.76 imagery 180 15.48 fibrosis 14 5.00

Disease Link Frequency Relevance Heat Vomiting 11 100.00 Pain 6 100.00 Hypertension 2 98.68 Pressure Volume 2 Under Development 3 97.80 Common Cold 1 95.44 Headache 8 95.04 Hallucination 3 94.24 Sleep Disorders 4 92.00 Arthralgia 1 88.40 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 1 77.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The most frequently reported AEs (occurring in ?

Positive_regulation (frequently) of Localization (reported) of AEs

1) Confidence 0.22 Published 2010 Journal Ann Gen Psychiatry Section Body Doc Link PMC2949853 Disease Relevance 1.10 Pain Relevance 0.17

Other AEs were reported in 20 of 234 patients, including nausea (2 patients), pain at the injection site (1), increased systolic/diastolic blood pressure (2), increased blood glucose (2), decreased white blood cell count (2), increased blood bilirubin (3), increased blood phosphorus (1), increased alanine aminotransferase (1), increased aspartate aminotransferase (1), hypertension (4), and hypotension (2).46 Effect of hepatic and renal impairment

Positive_regulation (increased) of Localization (reported) of AEs in blood associated with pain, pressure volume 2 under development, hypertension and vomiting

2) Confidence 0.09 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 0.51 Pain Relevance 0.13

Other AEs were reported in 20 of 234 patients, including nausea (2 patients), pain at the injection site (1), increased systolic/diastolic blood pressure (2), increased blood glucose (2), decreased white blood cell count (2), increased blood bilirubin (3), increased blood phosphorus (1), increased alanine aminotransferase (1), increased aspartate aminotransferase (1), hypertension (4), and hypotension (2).46 Effect of hepatic and renal impairment

Positive_regulation (increased) of Localization (reported) of AEs in blood associated with pain, pressure volume 2 under development, hypertension and vomiting

3) Confidence 0.09 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 0.51 Pain Relevance 0.13

The most frequently reported AEs (occurring in ?

Positive_regulation (frequently) of Localization (reported) of AEs

4) Confidence 0.08 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2958874 Disease Relevance 0.49 Pain Relevance 0.12

General Comments

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