INT327119

Context Info Confidence 0.12 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 2.47 Pain Relevance 0.74

mitochondrion (HCCS) lyase activity (HCCS)

Anatomy Link Frequency bile 2 HCCS (Homo sapiens)

Pain Link Frequency Relevance Heat Bile 68 99.96 imagery 360 75.68 fibrosis 28 5.00 Pain 12 5.00 headache 8 5.00 agonist 4 5.00 cva 4 5.00 alcohol 4 5.00

Disease Link Frequency Relevance Heat Hepatocellular Cancer 128 94.84 Cancer 96 80.96 Hemangioma 44 72.48 Metastasis 104 33.52 Cirrhosis 44 5.00 Focal Nodular Hyperplasia 40 5.00 Adenoma 32 5.00 Liver Cancer 32 5.00 Hypersensitivity 28 5.00 Hepatitis C Virus Infection 20 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Histopathologically, 4 gadoxetic acid-positive HCCs and 5 gadoxetic acid-negative HCCs produced bile.

Gene_expression (produced) of HCCs in bile associated with bile

1) Confidence 0.12 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 0.59 Pain Relevance 0.19

Histopathologically, 4 gadoxetic acid-positive HCCs and 5 gadoxetic acid-negative HCCs produced bile.

Gene_expression (produced) of HCCs in bile associated with bile

2) Confidence 0.12 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 0.58 Pain Relevance 0.18

HCCs with gadoxetic acid uptake overexpressed OATP1B3 compared with HCCs without gadoxetic acid uptake, and OATP1B3 levels were significantly correlated with ERs (r = 0.91, P < 0.0001).

Neg (without) Gene_expression (overexpressed) of HCCs

3) Confidence 0.10 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 0.65 Pain Relevance 0.18

HCCs with gadoxetic acid uptake overexpressed OATP1B3 compared with HCCs without gadoxetic acid uptake, and OATP1B3 levels were significantly correlated with ERs (r = 0.91, P < 0.0001).

Gene_expression (overexpressed) of HCCs

4) Confidence 0.10 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 0.65 Pain Relevance 0.19

General Comments

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