INT327169

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.81
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mpl)
Anatomy Link Frequency
brain 4
astrocytes 4
cortex 3
hippocampus 1
Mpl (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 54 98.16 Very High Very High Very High
Central nervous system 84 90.36 High High
Inflammatory response 6 66.72 Quite High
cerebral cortex 42 60.72 Quite High
ischemia 6 48.96 Quite Low
Thalamus 30 32.72 Quite Low
medulla 48 24.24 Low Low
Spinal cord 48 19.36 Low Low
midbrain 24 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 24 99.98 Very High Very High Very High
Congenital Anomalies 48 77.52 Quite High
Targeted Disruption 24 71.60 Quite High
Meningitis 6 68.80 Quite High
INFLAMMATION 6 66.36 Quite High
Syndrome 24 61.76 Quite High
Thrombocytopenia 36 61.12 Quite High
Cv Unclassified Under Development 6 48.96 Quite Low
Cerebral Hypoxia 6 48.60 Quite Low
Apoptosis 24 45.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under hypoxia Mpl mRNA levels increased in astrocytes, but decreased in hippocampal neurons, suggesting a differential regulation under certain conditions [3].
Positive_regulation (increased) of Transcription (levels) of Mpl in astrocytes associated with hypoxia
1) Confidence 0.50 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.57 Pain Relevance 0.29
Either the sensitivity of immunohistochemistry is too low to detect Mpl expression in brain tissue specimens, or in vitro conditions cause up-regulation of Mpl mRNA expression.
Positive_regulation (regulation) of Transcription (expression) of Mpl in brain
2) Confidence 0.47 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.37 Pain Relevance 0
Previous data obtained by conventional RT-PCR showed slightly higher Mpl mRNA expression in the fetal rat brain compared to adult rat hippocampus and cortex [3].
Positive_regulation (higher) of Transcription (expression) of Mpl in cortex associated with hippocampus
3) Confidence 0.47 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.06 Pain Relevance 0.05
Either the sensitivity of immunohistochemistry is too low to detect Mpl expression in brain tissue specimens, or in vitro conditions cause up-regulation of Mpl mRNA expression.
Positive_regulation (cause) of Transcription (expression) of Mpl in brain
4) Confidence 0.47 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.37 Pain Relevance 0
The later hypothesis appears to be more likely, since Mpl mRNA expression in astrocytes is known to be induced by hypoxia [3].
Positive_regulation (induced) of Transcription (expression) of Mpl in astrocytes associated with hypoxia
5) Confidence 0.47 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.37 Pain Relevance 0
Previous data obtained by conventional RT-PCR showed slightly higher Mpl mRNA expression in the fetal rat brain compared to adult rat hippocampus and cortex [3].
Positive_regulation (higher) of in hippocampus Transcription (expression) of Mpl in cortex associated with hippocampus
6) Confidence 0.16 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.06 Pain Relevance 0.05

General Comments

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