INT327172

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 2.32
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mpl)
Anatomy Link Frequency
astrocytes 4
rhombencephalon 4
cerebellum 3
brain 2
diencephalon 2
Mpl (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 182 99.68 Very High Very High Very High
Thalamus 65 99.12 Very High Very High Very High
midbrain 52 99.04 Very High Very High Very High
Hippocampus 117 98.76 Very High Very High Very High
Spinal cord 104 98.60 Very High Very High Very High
medulla 104 94.00 High High
cerebral cortex 91 93.52 High High
Inflammatory response 13 81.72 Quite High
cva 13 80.96 Quite High
imagery 13 80.20 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 52 99.92 Very High Very High Very High
Neurodegenerative Disease 52 98.52 Very High Very High Very High
Brain Injury 13 94.76 High High
Congenital Anomalies 104 93.56 High High
Thrombocytopenia 78 90.68 High High
Syndrome 52 90.28 High High
Apoptosis 52 89.84 High High
Targeted Disruption 52 87.84 High High
Stroke 13 85.92 High High
Meningitis 13 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The second major developmental change in Mpl expression affects the cerebellum.
Regulation (change) of Gene_expression (expression) of Mpl in cerebellum
1) Confidence 0.62 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.30 Pain Relevance 0.12
However, data on the expression and regulation of Mpl in the CNS are very limited.
Regulation (data) of Gene_expression (expression) of Mpl associated with central nervous system
2) Confidence 0.45 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.52 Pain Relevance 0.37
To validate the Mpl antibody, freshly-cut 14 ?
Regulation (validate) of Gene_expression (antibody) of Mpl
3) Confidence 0.45 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.09 Pain Relevance 0.04
Widespread Mpl expression was found in the diencephalon (thalamus and hypothalamus) and mesencephalon (superior and inferior colliculus); other areas included the pons (metencephalon), medulla (myelencephalon), and the grey matter of the cervical spinal cord (Figure 2 D-G, Table 1).
Regulation (found) of Gene_expression (expression) of Mpl in diencephalon associated with medulla, thalamus and spinal cord
4) Confidence 0.45 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.40
From E18 onwards Mpl protein expression was detectable in the prosencephalon, midbrain, and rhombencephalon as well as in the spinal cord (Table 1).
Regulation (detectable) of Gene_expression (expression) of Mpl protein in rhombencephalon associated with midbrain and spinal cord
5) Confidence 0.45 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.36
Developmental changes in Mpl and Thpo mRNA expression throughout development
Regulation (changes) of Gene_expression (expression) of Mpl
6) Confidence 0.45 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.04
Notably, the strongest variations of Mpl expression occur in the telencephalon and in the metencephalon: In the telencephalon, Mpl-positive cells are initially located in the cortical subventricular zone and in the caudal cortex (Figures 2H, I), but not in the developing white matter.
Regulation (variations) of Gene_expression (expression) of Mpl in cortex
7) Confidence 0.45 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.20
The hypoxic up-regulation of Mpl expression in astrocytes contrasts the down-regulation of the Mpl in neuronal cells under the same conditions [3], raising the question whether the Thpo/Mpl system exhibits a different role in astrocytes vs. neurons.
Regulation (regulation) of Gene_expression (expression) of Mpl in astrocytes associated with hypoxia
8) Confidence 0.27 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.37 Pain Relevance 0
Due to the developmental changes in Mpl expression in the SVZ of the telencephalon and in the cerebellum (downregulation in the white matter; upregulation in Purkinje cells) as well as structural and functional abnormalities in the brain of some patients with impaired Mpl function (CAMT, TAR syndrome) affecting particularly the cerebellum [16,19-21], we expected structural abnormalities in the brain of mutant mice with homozygous Mpl deficiency.
Regulation (changes) of in telencephalon Gene_expression (expression) of Mpl in cerebellum associated with syndrome, congenital anomalies and thrombocytopenia
9) Confidence 0.27 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.91 Pain Relevance 0.04
Amplification of Mpl transcripts showed the presence of Mpl expression not only in neurons, but also in cultured astrocytes (Figure 5A).
Regulation (presence) of Gene_expression (expression) of Mpl in astrocytes
10) Confidence 0.27 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.05 Pain Relevance 0
To further elucidate the role of the Thpo/Mpl system in the brain, we analysed herein the expression pattern of the Mpl protein in the murine brain by immunohistochemistry.
Regulation (role) of Gene_expression (expression) of Mpl protein in brain
11) Confidence 0.27 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.08 Pain Relevance 0.03
From E18 onwards Mpl protein expression was detectable in the prosencephalon, midbrain, and rhombencephalon as well as in the spinal cord (Table 1).
Regulation (detectable) of in midbrain Gene_expression (expression) of Mpl protein in rhombencephalon associated with midbrain and spinal cord
12) Confidence 0.15 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.36
From E18 onwards Mpl protein expression was detectable in the prosencephalon, midbrain, and rhombencephalon as well as in the spinal cord (Table 1).
Regulation (detectable) of in prosencephalon Gene_expression (expression) of Mpl protein in rhombencephalon associated with midbrain and spinal cord
13) Confidence 0.15 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.36

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