INT327173

Context Info Confidence 0.43 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.87 Pain Relevance 0.29

plasma membrane (Mpl)

Anatomy Link Frequency neuronal stem cells 2 astrocytes 2 Mpl (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 18 95.24 Central nervous system 28 90.36 Inflammatory response 2 66.72 cerebral cortex 14 60.72 ischemia 2 48.96 cva 2 37.28 Spinal cord 16 5.00 medulla 16 5.00 Thalamus 10 5.00 midbrain 8 5.00

Disease Link Frequency Relevance Heat Hypoxia 8 99.98 Congenital Anomalies 16 79.84 Targeted Disruption 8 73.92 Meningitis 2 68.80 INFLAMMATION 2 66.36 Neurodegenerative Disease 8 66.32 Thrombocytopenia 12 57.44 Cv Unclassified Under Development 2 48.96 Cerebral Hypoxia 2 48.60 Syndrome 8 45.44

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Under hypoxia Mpl mRNA levels increased in astrocytes, but decreased in hippocampal neurons, suggesting a differential regulation under certain conditions [3].

Negative_regulation (decreased) of Transcription (levels) of Mpl in astrocytes associated with hypoxia

1) Confidence 0.43 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.58 Pain Relevance 0.29

In line with this report, we detected Mpl mRNA expression in primary cortical neurons, but not in neuronal stem cells (Figure 5).

Neg (not) Negative_regulation (detected) of Transcription (expression) of Mpl in neuronal stem cells

2) Confidence 0.43 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.28 Pain Relevance 0

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