INT327173

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mpl)
Anatomy Link Frequency
neuronal stem cells 2
astrocytes 2
Mpl (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 18 95.24 Very High Very High Very High
Central nervous system 28 90.36 High High
Inflammatory response 2 66.72 Quite High
cerebral cortex 14 60.72 Quite High
ischemia 2 48.96 Quite Low
cva 2 37.28 Quite Low
Spinal cord 16 5.00 Very Low Very Low Very Low
medulla 16 5.00 Very Low Very Low Very Low
Thalamus 10 5.00 Very Low Very Low Very Low
midbrain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 8 99.98 Very High Very High Very High
Congenital Anomalies 16 79.84 Quite High
Targeted Disruption 8 73.92 Quite High
Meningitis 2 68.80 Quite High
INFLAMMATION 2 66.36 Quite High
Neurodegenerative Disease 8 66.32 Quite High
Thrombocytopenia 12 57.44 Quite High
Cv Unclassified Under Development 2 48.96 Quite Low
Cerebral Hypoxia 2 48.60 Quite Low
Syndrome 8 45.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under hypoxia Mpl mRNA levels increased in astrocytes, but decreased in hippocampal neurons, suggesting a differential regulation under certain conditions [3].
Negative_regulation (decreased) of Transcription (levels) of Mpl in astrocytes associated with hypoxia
1) Confidence 0.43 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.58 Pain Relevance 0.29
In line with this report, we detected Mpl mRNA expression in primary cortical neurons, but not in neuronal stem cells (Figure 5).
Neg (not) Negative_regulation (detected) of Transcription (expression) of Mpl in neuronal stem cells
2) Confidence 0.43 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.28 Pain Relevance 0

General Comments

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