INT327176

Context Info Confidence 0.50 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.14 Pain Relevance 0.66

plasma membrane (Mpl)

Anatomy Link Frequency brain 2 hippocampus 2 Mpl (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 18 99.98 cerebral cortex 14 98.44 Spinal cord 16 92.72 Central nervous system 28 91.84 medulla 16 91.04 Thalamus 10 90.12 midbrain 8 60.16 anesthesia 2 5.00 ischemia 2 5.00 Inflammatory response 2 5.00

Disease Link Frequency Relevance Heat Congenital Anomalies 16 71.44 Apoptosis 8 66.84 Syndrome 8 32.32 Thrombocytopenia 12 31.04 Targeted Disruption 8 18.16 Hypoxia 8 5.00 Neurodegenerative Disease 8 5.00 Cv Unclassified Under Development 2 5.00 Stroke 2 5.00 Cv General 3 Under Development 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression pattern of Mpl in the developing brain

Positive_regulation (pattern) of Gene_expression (Expression) of Mpl in brain

1) Confidence 0.50 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.15

However, major developmental changes became obvious: In the subventricular zone of the cerebral cortex Mpl expression occurred only during late gestation, while in the hippocampus Mpl expression was detectable for first time at stage P4.

Positive_regulation (detectable) of Gene_expression (expression) of Mpl in hippocampus associated with hippocampus and cerebral cortex

2) Confidence 0.47 Published 2010 Journal BMC Dev Biol Section Abstract Doc Link PMC2921376 Disease Relevance 0.14 Pain Relevance 0.52

General Comments

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