INT327178

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Context Info
Confidence 0.72
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 18
Disease Relevance 4.16
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mpl)
Anatomy Link Frequency
brain 4
astrocytes 3
cortex 2
hippocampus 2
neuronal stem cells 1
Mpl (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 252 98.92 Very High Very High Very High
Hippocampus 162 98.84 Very High Very High Very High
Inflammatory response 18 78.44 Quite High
cerebral cortex 126 74.56 Quite High
ischemia 18 60.68 Quite High
Thalamus 90 41.76 Quite Low
cva 18 37.28 Quite Low
medulla 144 33.28 Quite Low
Spinal cord 144 28.40 Quite Low
imagery 18 25.52 Quite Low
Disease Link Frequency Relevance Heat
Hypoxia 72 99.98 Very High Very High Very High
Meningitis 18 80.52 Quite High
INFLAMMATION 18 78.08 Quite High
Congenital Anomalies 144 76.72 Quite High
Targeted Disruption 72 70.80 Quite High
Neurodegenerative Disease 72 66.32 Quite High
Syndrome 72 60.84 Quite High
Cv Unclassified Under Development 18 60.68 Quite High
Cerebral Hypoxia 18 60.32 Quite High
Thrombocytopenia 108 60.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
So far, expression of Mpl mRNA has been described in the CNS of mice, rats and humans [3,4].
Transcription (expression) of Mpl associated with central nervous system
1) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.56 Pain Relevance 0.32
Previous data obtained by conventional RT-PCR showed slightly higher Mpl mRNA expression in the fetal rat brain compared to adult rat hippocampus and cortex [3].
Transcription (expression) of Mpl in cortex associated with hippocampus
2) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.06 Pain Relevance 0.05
In line with this report, we detected Mpl mRNA expression in primary cortical neurons, but not in neuronal stem cells (Figure 5).
Transcription (expression) of Mpl in neuronal stem cells
3) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.28 Pain Relevance 0
This has been experimentally proven by comparing Mpl mRNA levels in perfused vs. non-perfused specimens of the adult mouse brain (Additional File 1).
Transcription (levels) of Mpl in adult mouse
4) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0
Beyond E 13.5, however, Mpl mRNA levels remained stable, which is concordant with the data obtained by immunohistochemistry.


Transcription (levels) of Mpl
5) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0
Thus, Mpl mRNA levels might be false high, if mRNA from circulating hematopoietic Mpl expressing progenitors has been amplified in PCR analysis.
Transcription (levels) of Mpl
6) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0
Furthermore, we examined the expression of Mpl mRNA in cultured primary brain cells, including neurons, astrocytes, and microglia prepared from the developing rat brain, and in neuronal stem cells prepared from adult mouse brain.
Spec (examined) Transcription (expression) of Mpl in brain
7) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0
Mpl mRNA expression was analysed in primary brain-derived cells by conventional RT-PCR analysis.
Spec (analysed) Transcription (expression) of Mpl in brain
8) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.04
Under hypoxia Mpl mRNA levels increased in astrocytes, but decreased in hippocampal neurons, suggesting a differential regulation under certain conditions [3].
Transcription (levels) of Mpl in astrocytes associated with hypoxia
9) Confidence 0.69 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.57 Pain Relevance 0.29
So far, expression of Mpl mRNA has been described in the CNS of mice, rats and humans [3,4].
Transcription (expression) of Mpl associated with central nervous system
10) Confidence 0.69 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.56 Pain Relevance 0.32
Either the sensitivity of immunohistochemistry is too low to detect Mpl expression in brain tissue specimens, or in vitro conditions cause up-regulation of Mpl mRNA expression.
Transcription (expression) of Mpl in brain
11) Confidence 0.53 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.37 Pain Relevance 0
Mpl transcript levels appeared to be higher at very early stages (E9.5 to E13.5) compared to the perinatal period and adulthood.
Transcription (levels) of Mpl
12) Confidence 0.53 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.03
Considerably high Mpl transcript levels may result in part from circulating hematopoietic cells as shown in our analysis of non-perfused brain tissue specimens (Additional File 1).
Transcription (levels) of Mpl in brain
13) Confidence 0.53 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.06 Pain Relevance 0.05
The later hypothesis appears to be more likely, since Mpl mRNA expression in astrocytes is known to be induced by hypoxia [3].
Transcription (expression) of Mpl in astrocytes associated with hypoxia
14) Confidence 0.53 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.37 Pain Relevance 0
Region-specific analysis revealed Mpl transcripts in the adult rat cortex and hippocampus.
Transcription (transcripts) of Mpl in cortex associated with hippocampus
15) Confidence 0.53 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.61 Pain Relevance 0.34
Amplification of Mpl transcripts showed the presence of Mpl expression not only in neurons, but also in cultured astrocytes (Figure 5A).
Transcription (transcripts) of Mpl in astrocytes
16) Confidence 0.53 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.05 Pain Relevance 0
Previous data obtained by conventional RT-PCR showed slightly higher Mpl mRNA expression in the fetal rat brain compared to adult rat hippocampus and cortex [3].
Transcription (expression) of Mpl in hippocampus associated with hippocampus
17) Confidence 0.24 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.06 Pain Relevance 0.05
Region-specific analysis revealed Mpl transcripts in the adult rat cortex and hippocampus.
Transcription (transcripts) of Mpl in hippocampus associated with hippocampus
18) Confidence 0.18 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.61 Pain Relevance 0.34

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