INT327179

Context Info Confidence 0.62 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 5 Disease Relevance 1.03 Pain Relevance 0.52

plasma membrane (Mpl)

Anatomy Link Frequency brain 3 astrocytes 1 Mpl (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 70 99.68 Hippocampus 45 84.16 Inflammatory response 5 80.64 cerebral cortex 35 74.64 Thalamus 25 72.08 medulla 40 63.60 ischemia 5 62.88 Spinal cord 40 58.72 midbrain 20 5.00 anesthesia 5 5.00

Disease Link Frequency Relevance Heat Hypoxia 20 98.68 Congenital Anomalies 40 83.72 Meningitis 5 82.72 INFLAMMATION 5 80.28 Cv Unclassified Under Development 5 62.88 Cerebral Hypoxia 5 62.52 Apoptosis 20 58.96 Syndrome 20 51.84 Thrombocytopenia 30 51.20 Targeted Disruption 20 43.12

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It becomes evident that the Mpl is developmentally regulated, since Mpl is not detectable on protein levels at the very early stages (E12 and E15) of brain development (Figure 2A-C).

Regulation (regulated) of Mpl in brain

1) Confidence 0.62 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.08 Pain Relevance 0.03

To further elucidate the role of the Thpo/Mpl system in the brain, we analysed herein the expression pattern of the Mpl protein in the murine brain by immunohistochemistry.

Regulation (role) of Mpl in brain

2) Confidence 0.45 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.08 Pain Relevance 0.03

However, data on the expression and regulation of Mpl in the CNS are very limited.

Regulation (regulation) of Mpl associated with central nervous system

3) Confidence 0.27 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.52 Pain Relevance 0.32

This may be important for future dissection of the regulation and function of the Thpo/Mpl system in the brain.

Regulation (regulation) of Mpl in brain

4) Confidence 0.27 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.14

The hypoxic up-regulation of Mpl expression in astrocytes contrasts the down-regulation of the Mpl in neuronal cells under the same conditions [3], raising the question whether the Thpo/Mpl system exhibits a different role in astrocytes vs. neurons.

Regulation (regulation) of Mpl in astrocytes associated with hypoxia

5) Confidence 0.24 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.35 Pain Relevance 0

General Comments

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