INT32718

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Context Info
Confidence 0.76
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 82
Total Number 83
Disease Relevance 9.43
Pain Relevance 48.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
Anatomy Link Frequency
ovary 15
embryonic kidney 7
brain 3
lymphocytes 3
NG108-15 3
OPRD1 (Homo sapiens)
OPRD1 - W284L (1)
Pain Link Frequency Relevance Heat
opioid receptor 473 100.00 Very High Very High Very High
agonist 265 100.00 Very High Very High Very High
Enkephalin 141 100.00 Very High Very High Very High
Opioid 133 100.00 Very High Very High Very High
narcan 74 100.00 Very High Very High Very High
Morphine 67 100.00 Very High Very High Very High
Delta opioid receptors 44 100.00 Very High Very High Very High
Opioid receptor 1 9 100.00 Very High Very High Very High
Endogenous opioid 28 99.84 Very High Very High Very High
mu opioid receptor 53 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 26 100.00 Very High Very High Very High
Autoimmune Hepatitis 6 99.98 Very High Very High Very High
Bordatella Infection 34 99.68 Very High Very High Very High
Lung Cancer 13 99.60 Very High Very High Very High
Arrhythmias 2 Under Development 12 99.36 Very High Very High Very High
Urological Neuroanatomy 2 99.36 Very High Very High Very High
Stress 3 99.16 Very High Very High Very High
Targeted Disruption 4 99.04 Very High Very High Very High
Hypoxia 4 99.02 Very High Very High Very High
Glioma 1 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are the first to show, on endogenously expressed human delta-opioid receptor, that a close link exists between receptor phosphorylation and agonist-promoted desensitization and that desensitization involves a GRK.
Gene_expression (expressed) of delta-opioid receptor associated with agonist and opioid receptor
1) Confidence 0.76 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9572300 Disease Relevance 0 Pain Relevance 0.49
The inhibitory response of [D-Pen2,D-Pen5]-enkephalin was dependent on the expression of the delta-opioid receptor and exhibited an EC50 of 1 nM.
Gene_expression (expression) of delta-opioid associated with opioid receptor and enkephalin
2) Confidence 0.75 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7760050 Disease Relevance 0.08 Pain Relevance 0.81
Experiments compared the abilities of the three drugs to competitively inhibit [3H]naltrindole binding and also stimulate [35S]GTPgammaS binding in membranes prepared from stably transfected Chinese hamster ovary (CHO) cells that express the cloned human delta-opioid receptor.
Gene_expression (express) of delta-opioid receptor in ovary associated with opioid receptor
3) Confidence 0.75 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9178661 Disease Relevance 0 Pain Relevance 0.33
The Eu-diethylenetriaminepentaacetic acid (DTPA)-[D-Pen(2),l-Cys(5)] enkephalin (DPLCE) ligand bound to Chinese hamster ovary (CHO) cells overexpressing the human delta-opioid receptor with affinity similar to the unlabeled ligand.
Gene_expression (overexpressing) of delta-opioid receptor in ovary associated with opioid receptor and enkephalin
4) Confidence 0.72 Published 2005 Journal Anal. Biochem. Section Abstract Doc Link 16004955 Disease Relevance 0 Pain Relevance 0.23
In NG108-15 cells, NDMC inhibited cyclic AMP formation and stimulated the phosphorylation of extracellular signal-regulated kinase 1/2 by activating the endogenously expressed delta-opioid receptor.
Gene_expression (expressed) of delta-opioid receptor in NG108-15 associated with opioid receptor
5) Confidence 0.69 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16841075 Disease Relevance 0 Pain Relevance 0.66
Therefore, we measured the binding and functional selectivity of several putative delta(1)- and delta(2)-opioid receptor-selective compounds in membranes from Chinese hamster ovary cells stably expressing the human delta-opioid receptor.
Gene_expression (expressing) of delta-opioid receptor in ovary associated with opioid receptor
6) Confidence 0.68 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12242086 Disease Relevance 0 Pain Relevance 0.47
The present study aimed to investigate the pharmacological properties of delta1- and delta2-opioid subtypes expressed in the human neuroblastoma cell line SK-N-BE and to characterize their putative corresponding mRNAs.
Gene_expression (expressed) of delta2-opioid associated with neuroblastoma and opioid
7) Confidence 0.65 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10692556 Disease Relevance 0.17 Pain Relevance 0.48
Delta opioid receptor gene expression in lymphocytes.
Gene_expression (expression) of Delta opioid receptor gene in lymphocytes associated with opioid receptor
8) Confidence 0.61 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 8060306 Disease Relevance 0.10 Pain Relevance 0.44
The current study characterizes the molecular structure of the delta opioid receptor and its gene expression level in lung cancer cell lines relative to normal human lung using a sensitive RT-PCR approach.
Gene_expression (expression) of delta opioid receptor in lung associated with lung cancer and opioid receptor
9) Confidence 0.59 Published 1998 Journal Anticancer Res. Section Abstract Doc Link 9673405 Disease Relevance 0.60 Pain Relevance 0.16
Oligomerization of the human delta-opioid receptor and its regulation by ligand occupancy were explored following expression in HEK293 cells using each of co-immunoprecipitation of differentially epitope-tagged forms of the receptor, bioluminescence resonance energy transfer and time-resolved fluorescence resonance energy transfer.
Gene_expression (expression) of delta-opioid receptor associated with opioid receptor
10) Confidence 0.59 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278447 Disease Relevance 0 Pain Relevance 0.24
These studies demonstrate that, following transient transfection of HEK293 cells, constitutively formed oligomers of the human delta-opioid receptor can be detected by a variety of approaches.
Gene_expression (detected) of delta-opioid receptor associated with opioid receptor
11) Confidence 0.59 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278447 Disease Relevance 0 Pain Relevance 0.34
Co-transfection of the delta-opioid receptor with type II adenylyl cyclase and an activated mutant of alpha s converted the delta-opioid signal from inhibition to stimulation of cAMP accumulation.
Gene_expression (Co-transfection) of delta-opioid associated with opioid receptor and opioid
12) Confidence 0.58 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7760050 Disease Relevance 0.17 Pain Relevance 0.95
Numerical density of delta-opioid receptor expressing neurons in the frontal cortex of drug-related fatalities.
Gene_expression (expressing) of delta-opioid receptor in frontal cortex associated with urological neuroanatomy and opioid receptor
13) Confidence 0.57 Published 2000 Journal Forensic Sci. Int. Section Title Doc Link 10978658 Disease Relevance 0.10 Pain Relevance 0.55
Intrinsic activities of different delta opioid agonists were determined in a [35S]GTPgammaS binding assay using cell membranes from Chinese hamster ovary (CHO) cells stably expressing the wild type (hDOR/CHO) or W284L mutant human delta opioid receptor (W284L/CHO).
Gene_expression (expressing) of delta opioid receptor (W284L) in CHO associated with mu agonist and opioid receptor
14) Confidence 0.56 Published 2001 Journal Life Sci. Section Abstract Doc Link 11358332 Disease Relevance 0 Pain Relevance 0.40
In CHO cells expressing the delta-opioid receptor (CHO/DOR), NDMC behaved as a full agonist both in stimulating [(35)S]GTPgammaS binding (pEC(50)=7.24) and in inhibiting cyclic AMP formation (pEC(50)=6.40).
Gene_expression (expressing) of delta-opioid receptor in CHO associated with agonist and opioid receptor
15) Confidence 0.53 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16841075 Disease Relevance 0 Pain Relevance 0.36
Displacement analysis revealed that a variety of opioid peptides were found to be ineffective in displacing specifically bound 3H dihydromorphine and only delta2 ligands were effective in regard to 3H Ala2-met5 enkephalinamide (DAMA), indicating the presence of mu3 and delta2 opioid receptor sites, respectively.
Gene_expression (presence) of delta2 opioid receptor associated with opioid receptor and opioid
16) Confidence 0.53 Published 1998 Journal Int. J. Cardiol. Section Abstract Doc Link 9687092 Disease Relevance 0 Pain Relevance 0.63
Comparative pharmacological properties and functional coupling of mu and delta opioid receptor sites in human neuroblastoma SH-SY5Y cells.
Gene_expression (properties) of delta opioid receptor in SH-SY5Y associated with neuroblastoma, enkephalin and opioid receptor
17) Confidence 0.51 Published 1987 Journal Mol. Pharmacol. Section Title Doc Link 3037297 Disease Relevance 0.19 Pain Relevance 0.98
To investigate the role of G-protein beta gamma subunits in delta-opioid signal transduction, we have transfected Chinese hamster ovary (CHO) cells stably expressing the human delta-opioid receptor (hDOR/CHO cells) with the G(alpha)-subunit of transducin-1 (hDOR/T1/CHO).
Gene_expression (expressing) of delta-opioid receptor in CHO associated with opioid receptor and opioid
18) Confidence 0.49 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641436 Disease Relevance 0 Pain Relevance 0.26
We show that cells stably expressing the human delta-opioid receptor exhibited a pertussis toxin-sensitive cAMP overshoot in response to chronic application of SNC80.
Gene_expression (expressing) of delta-opioid receptor associated with bordatella infection and opioid receptor
19) Confidence 0.49 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641436 Disease Relevance 0.10 Pain Relevance 0.26
A human neuroblastoma cell line expresses mu and delta opioid receptor sites.
Gene_expression (expresses) of delta opioid receptor associated with neuroblastoma, enkephalin and opioid receptor
20) Confidence 0.48 Published 1986 Journal J. Biol. Chem. Section Title Doc Link 3003051 Disease Relevance 0.35 Pain Relevance 0.62

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