INT327181

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.74
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mpl)
Anatomy Link Frequency
corpus callosum 1
cerebellum 1
Mpl (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 28 83.80 Quite High
Hippocampus 18 64.92 Quite High
cva 2 64.60 Quite High
Inflammatory response 2 36.40 Quite Low
cerebral cortex 14 30.40 Quite Low
ischemia 2 18.64 Low Low
Spinal cord 16 5.00 Very Low Very Low Very Low
medulla 16 5.00 Very Low Very Low Very Low
Thalamus 10 5.00 Very Low Very Low Very Low
midbrain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 8 99.72 Very High Very High Very High
Congenital Anomalies 16 99.10 Very High Very High Very High
Thrombocytopenia 12 99.08 Very High Very High Very High
Targeted Disruption 8 85.28 High High
Brain Injury 2 78.40 Quite High
Apoptosis 8 73.48 Quite High
Hypoxia 8 69.64 Quite High
Stroke 2 69.56 Quite High
Cv General 3 Under Development 2 64.60 Quite High
Neurodegenerative Disease 8 55.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the thrombocytopenia and absent radii (TAR) syndrome, for which a defect in Mpl signalling has been shown [18], cerebellar dysgenesis either with/without agenesis of the corpus callosum and delayed myelinisation have been reported [19-21].
Negative_regulation (defect) of Mpl in corpus callosum associated with congenital anomalies, syndrome and thrombocytopenia
1) Confidence 0.43 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.72 Pain Relevance 0.17
Due to the developmental changes in Mpl expression in the SVZ of the telencephalon and in the cerebellum (downregulation in the white matter; upregulation in Purkinje cells) as well as structural and functional abnormalities in the brain of some patients with impaired Mpl function (CAMT, TAR syndrome) affecting particularly the cerebellum [16,19-21], we expected structural abnormalities in the brain of mutant mice with homozygous Mpl deficiency.
Negative_regulation (deficiency) of Mpl in cerebellum associated with syndrome, congenital anomalies and thrombocytopenia
2) Confidence 0.43 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 1.02 Pain Relevance 0.03

General Comments

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