INT32719

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Context Info
Confidence 0.00
First Reported 1984
Last Reported 1985
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENG) cell motility (ENG) cell adhesion (ENG)
nucleolus (ENG) nucleus (ENG) cytoplasm (ENG)
Anatomy Link Frequency
plasma 1
third ventricle 1
ENG (Homo sapiens)
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 3 99.50 Very High Very High Very High
antagonist 5 98.52 Very High Very High Very High
opioid receptor 2 83.24 Quite High
Central nervous system 1 72.00 Quite High
amygdala 1 40.80 Quite Low
midbrain 1 40.00 Quite Low
narcan 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to determine the site(s) at which the opioid peptide beta-endorphin (beta-END) acts to influence plasma LH and PRL levels in the ovariectomized (OVX) rat. beta-END, administered into the third ventricle of conscious OVX rats fitted with jugular catheters, significantly decreased plasma LH in doses greater than or equal to 50 ng and increased PRL levels at all doses administered (10, 50, 100 and 250 ng) in a dose dependent fashion.
beta-END Regulation (influence) of LH in third ventricle associated with opioid
1) Confidence 0.00 Published 1984 Journal Life Sci. Section Abstract Doc Link 6323905 Disease Relevance 0 Pain Relevance 0.23
The delta antagonist ICI 154, 129, but not the mu1 or mu antagonists naloxazone or beta-funaltrexamine, respectively, blocked the suppressive effect of beta-END on plasma LH levels and transiently but significantly increased LH levels above preinfusion value.
beta-END Regulation (effect) of LH in plasma associated with antagonist
2) Confidence 0.00 Published 1985 Journal Endocrinology Section Abstract Doc Link 2981076 Disease Relevance 0 Pain Relevance 0.41

General Comments

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