INT327227

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 12.08
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ttpa) transport (Ttpa) intracellular (Ttpa)
cytoplasm (Ttpa)
Ttpa (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 363 99.62 Very High Very High Very High
Inflammation 1276 99.52 Very High Very High Very High
Kinase C 44 84.96 Quite High
chemokine 110 5.00 Very Low Very Low Very Low
cINOD 55 5.00 Very Low Very Low Very Low
Arthritis 55 5.00 Very Low Very Low Very Low
Inflammatory response 44 5.00 Very Low Very Low Very Low
Inflammatory stimuli 33 5.00 Very Low Very Low Very Low
aspirin 11 5.00 Very Low Very Low Very Low
Inflammatory mediators 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1320 99.52 Very High Very High Very High
Cancer 1584 99.44 Very High Very High Very High
Hepatocellular Cancer 22 97.20 Very High Very High Very High
Renal Cancer 22 97.12 Very High Very High Very High
Breast Cancer 55 96.24 Very High Very High Very High
Glioma 22 95.28 Very High Very High Very High
Hypoxia 121 94.08 High High
Disease 99 89.36 High High
Chronic Disease 11 82.32 Quite High
Inflammatory Bowel Disease 44 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the loss of post-transcriptional regulation due to decreased expression of mRNA decay proteins such as TTP can occur with different mechanisms and allow enhanced expression of common inflammation and cancer genes.
Gene_expression (expression) of TTP associated with inflammation and cancer
1) Confidence 0.08 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.27 Pain Relevance 0.34
Elevated HuR expression occurs with the loss of TTP expression at an early stage of colorectal tumorigenesis that is associated with increased COX-2 expression [71].
Gene_expression (expression) of TTP
2) Confidence 0.08 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.80 Pain Relevance 0.19
An indirect involvement of TTP dysfunction in chronic inflammatory conditions may be deduced from the observation that the anti-inflammatory cytokine, IL-10, increases TTP expression and subsequently reduces the pro-inflammatory cytokines, TNF-?
Gene_expression (expression) of TTP associated with inflammation and cytokine
3) Confidence 0.08 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.42 Pain Relevance 0.58
Also, under-expression of RNA destabilizing proteins such as TTP can lead to increase in AU-rich mRNAs that are involved in chronic inflammation and cancer.
Gene_expression (expression) of TTP associated with inflammation and cancer
4) Confidence 0.08 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.13 Pain Relevance 0.22
Loss of TTP expression and function in cancer and chronic inflammation
Gene_expression (expression) of TTP associated with inflammation and cancer
5) Confidence 0.07 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.01 Pain Relevance 0.22
An indirect involvement of TTP dysfunction in chronic inflammatory conditions may be deduced from the observation that the anti-inflammatory cytokine, IL-10, increases TTP expression and subsequently reduces the pro-inflammatory cytokines, TNF-?
Gene_expression (dysfunction) of TTP associated with inflammation and cytokine
6) Confidence 0.07 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.40 Pain Relevance 0.47
It is not necessarily that TTP levels are reduced in order to observe reduced TTP-induced mRNA decay, since phosphorylation of TTP due to aberration in signaling pathways, such as overactivated p38 MAPK, is a defect that is observed in several cancers.
Gene_expression (levels) of TTP associated with cancer
7) Confidence 0.07 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.85 Pain Relevance 0.13
Since the ERK pathway is overactivated in cancer, it is thought that ERK activation results in phosphorylation of TTP, leading to an increase in TTP mRNA targets such as VEGF [72].
Gene_expression (targets) of TTP mRNA associated with cancer
8) Confidence 0.07 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.91 Pain Relevance 0.05
Here, loss of TTP can be linked to overexpression of TTP mRNA targets that are involved in inflammation and cancer such as VEGF [163].
Gene_expression (overexpression) of TTP mRNA associated with inflammation and cancer
9) Confidence 0.07 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.93 Pain Relevance 0.07
This effect may be mediated by TTP down-regulation since VHL decreases TTP expression [178].
Gene_expression (expression) of TTP
10) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.23 Pain Relevance 0.03
Possible loss of TTP and probably other ARE-mRNA decay-promoting proteins is overexpression of miRNAs that target the mRNAs of these proteins; the miR-29a which may be overexpressed in breast cancer tissues can suppress TTP [165].
Gene_expression (overexpression) of TTP associated with breast cancer
11) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.13 Pain Relevance 0.22

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