INT327228

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.07 Pain Relevance 0.40

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)

Elavl1 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 8 98.92 Inflammation 232 85.12 cytokine 66 82.24 chemokine 20 5.00 cINOD 10 5.00 Arthritis 10 5.00 Inflammatory response 8 5.00 Inflammatory stimuli 6 5.00 aspirin 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Cancer 288 99.52 Breast Cancer 10 99.48 INFLAMMATION 240 85.12 Colon Cancer 16 45.00 Lung Cancer 4 41.20 Metastasis 18 40.00 Hyperplasia 10 28.96 Glioblastoma 2 21.68 Ovarian Cancer 4 11.44 Hypoxia 22 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HuR phosphorylation by p38 MAPK, cAMP kinase, PKC, and cell-cycle G2-phase kinase Cdk1 can regulate HuR shuttling and thus affect the mRNA stabilization outcome [128, 160, 161].

Phosphorylation (phosphorylation) of HuR associated with kinase c

1) Confidence 0.38 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.06 Pain Relevance 0.19

Aberrations in the expression or activity of these kinases in cancer can lead to changes in HuR phosphorylation that favor cytoplasmic localization of HuR.

Phosphorylation (phosphorylation) of HuR associated with cancer

2) Confidence 0.38 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.02 Pain Relevance 0.21

General Comments

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