INT327228

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.07
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)
Elavl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 8 98.92 Very High Very High Very High
Inflammation 232 85.12 High High
cytokine 66 82.24 Quite High
chemokine 20 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Inflammatory stimuli 6 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 288 99.52 Very High Very High Very High
Breast Cancer 10 99.48 Very High Very High Very High
INFLAMMATION 240 85.12 High High
Colon Cancer 16 45.00 Quite Low
Lung Cancer 4 41.20 Quite Low
Metastasis 18 40.00 Quite Low
Hyperplasia 10 28.96 Quite Low
Glioblastoma 2 21.68 Low Low
Ovarian Cancer 4 11.44 Low Low
Hypoxia 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HuR phosphorylation by p38 MAPK, cAMP kinase, PKC, and cell-cycle G2-phase kinase Cdk1 can regulate HuR shuttling and thus affect the mRNA stabilization outcome [128, 160, 161].
Phosphorylation (phosphorylation) of HuR associated with kinase c
1) Confidence 0.38 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.06 Pain Relevance 0.19
Aberrations in the expression or activity of these kinases in cancer can lead to changes in HuR phosphorylation that favor cytoplasmic localization of HuR.
Phosphorylation (phosphorylation) of HuR associated with cancer
2) Confidence 0.38 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.02 Pain Relevance 0.21

General Comments

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