INT327230

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.97
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ttpa) transport (Ttpa) intracellular (Ttpa)
cytoplasm (Ttpa)
Ttpa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 348 98.80 Very High Very High Very High
cytokine 99 59.92 Quite High
Kinase C 12 29.40 Quite Low
chemokine 30 5.00 Very Low Very Low Very Low
cINOD 15 5.00 Very Low Very Low Very Low
Arthritis 15 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Inflammatory stimuli 9 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 360 98.80 Very High Very High Very High
Cancer 432 98.30 Very High Very High Very High
Hepatocellular Cancer 6 97.20 Very High Very High Very High
Breast Cancer 15 96.24 Very High Very High Very High
Glioma 6 95.28 Very High Very High Very High
Chronic Disease 3 38.96 Quite Low
Inflammatory Bowel Disease 12 36.96 Quite Low
Hypoxia 33 5.00 Very Low Very Low Very Low
Metastasis 27 5.00 Very Low Very Low Very Low
Disease 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the ERK pathway is overactivated in cancer, it is thought that ERK activation results in phosphorylation of TTP, leading to an increase in TTP mRNA targets such as VEGF [72].
Positive_regulation (increase) of Gene_expression (targets) of TTP mRNA associated with cancer
1) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.91 Pain Relevance 0.05
Here, loss of TTP can be linked to overexpression of TTP mRNA targets that are involved in inflammation and cancer such as VEGF [163].
Positive_regulation (overexpression) of Gene_expression (overexpression) of TTP mRNA associated with inflammation and cancer
2) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.93 Pain Relevance 0.07
Possible loss of TTP and probably other ARE-mRNA decay-promoting proteins is overexpression of miRNAs that target the mRNAs of these proteins; the miR-29a which may be overexpressed in breast cancer tissues can suppress TTP [165].
Positive_regulation (overexpression) of Gene_expression (overexpression) of TTP associated with breast cancer
3) Confidence 0.04 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.13 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox