INT327234

Context Info Confidence 0.20 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 3.04 Pain Relevance 0.37

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)

Elavl1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 464 90.00 cytokine 132 88.12 Kinase C 16 69.28 chemokine 40 5.00 cINOD 20 5.00 Arthritis 20 5.00 Inflammatory response 16 5.00 Inflammatory stimuli 12 5.00 aspirin 4 5.00 Inflammatory mediators 4 5.00

Disease Link Frequency Relevance Heat Colon Cancer 32 98.86 Hypoxia 44 96.32 Cancer 576 90.44 INFLAMMATION 480 90.00 Breast Cancer 20 68.56 Ovarian Cancer 8 67.68 Disease 36 63.72 Renal Cancer 8 58.96 Mantle-cell Lymphoma 4 53.60 Glioblastoma 4 47.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A number of RNA-binding proteins, e.g., HuR and PTB (polypyrimidine tract-binding protein), bind to U-rich/AU-rich region of VEGF and HIF 3?

Negative_regulation (number) of HuR

1) Confidence 0.20 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.95 Pain Relevance 0.04

These events allow the prevalence of HuR stabilizing action.

Negative_regulation (prevalence) of HuR

2) Confidence 0.19 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.92 Pain Relevance 0.20

Knockdown of HuR also leads to decreased cellular growth and VEGF expression in colorectal cancer cells [144]. miR-519 represses HuR translation, in turn reducing HuR-regulated gene expression and cell division [145].

Negative_regulation (reducing) of HuR associated with colon cancer

3) Confidence 0.19 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.61 Pain Relevance 0.06

Knockdown of HuR also leads to decreased cellular growth and VEGF expression in colorectal cancer cells [144]. miR-519 represses HuR translation, in turn reducing HuR-regulated gene expression and cell division [145].

Negative_regulation (Knockdown) of HuR associated with colon cancer

4) Confidence 0.19 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.56 Pain Relevance 0.07

General Comments

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