INT327234

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.04
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)
Elavl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 464 90.00 High High
cytokine 132 88.12 High High
Kinase C 16 69.28 Quite High
chemokine 40 5.00 Very Low Very Low Very Low
cINOD 20 5.00 Very Low Very Low Very Low
Arthritis 20 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
Inflammatory stimuli 12 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 32 98.86 Very High Very High Very High
Hypoxia 44 96.32 Very High Very High Very High
Cancer 576 90.44 High High
INFLAMMATION 480 90.00 High High
Breast Cancer 20 68.56 Quite High
Ovarian Cancer 8 67.68 Quite High
Disease 36 63.72 Quite High
Renal Cancer 8 58.96 Quite High
Mantle-cell Lymphoma 4 53.60 Quite High
Glioblastoma 4 47.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A number of RNA-binding proteins, e.g., HuR and PTB (polypyrimidine tract-binding protein), bind to U-rich/AU-rich region of VEGF and HIF 3?
Negative_regulation (number) of HuR
1) Confidence 0.20 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.95 Pain Relevance 0.04
These events allow the prevalence of HuR stabilizing action.
Negative_regulation (prevalence) of HuR
2) Confidence 0.19 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.92 Pain Relevance 0.20
Knockdown of HuR also leads to decreased cellular growth and VEGF expression in colorectal cancer cells [144]. miR-519 represses HuR translation, in turn reducing HuR-regulated gene expression and cell division [145].
Negative_regulation (reducing) of HuR associated with colon cancer
3) Confidence 0.19 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.61 Pain Relevance 0.06
Knockdown of HuR also leads to decreased cellular growth and VEGF expression in colorectal cancer cells [144]. miR-519 represses HuR translation, in turn reducing HuR-regulated gene expression and cell division [145].
Negative_regulation (Knockdown) of HuR associated with colon cancer
4) Confidence 0.19 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.56 Pain Relevance 0.07

General Comments

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