INT327244

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 5.23
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ttpa) transport (Ttpa) intracellular (Ttpa)
cytoplasm (Ttpa)
Ttpa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 580 98.56 Very High Very High Very High
cytokine 165 94.24 High High
Kinase C 20 85.28 High High
chemokine 50 5.00 Very Low Very Low Very Low
cINOD 25 5.00 Very Low Very Low Very Low
Arthritis 25 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
Inflammatory stimuli 15 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 720 99.32 Very High Very High Very High
INFLAMMATION 600 98.56 Very High Very High Very High
Breast Cancer 25 98.28 Very High Very High Very High
Glioma 10 81.12 Quite High
Hepatocellular Cancer 10 79.20 Quite High
Chronic Disease 5 59.12 Quite High
Inflammatory Bowel Disease 20 57.12 Quite High
Colon Cancer 40 28.32 Quite Low
Lung Cancer 10 24.52 Low Low
Metastasis 45 23.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the loss of post-transcriptional regulation due to decreased expression of mRNA decay proteins such as TTP can occur with different mechanisms and allow enhanced expression of common inflammation and cancer genes.
Negative_regulation (loss) of Gene_expression (expression) of TTP associated with inflammation and cancer
1) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.29 Pain Relevance 0.34
Elevated HuR expression occurs with the loss of TTP expression at an early stage of colorectal tumorigenesis that is associated with increased COX-2 expression [71].
Negative_regulation (loss) of Gene_expression (expression) of TTP
2) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.80 Pain Relevance 0.19
Loss of TTP expression and function in cancer and chronic inflammation
Negative_regulation (Loss) of Gene_expression (expression) of TTP associated with inflammation and cancer
3) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.01 Pain Relevance 0.22
Thus, the loss of post-transcriptional regulation due to decreased expression of mRNA decay proteins such as TTP can occur with different mechanisms and allow enhanced expression of common inflammation and cancer genes.
Negative_regulation (decreased) of Gene_expression (expression) of TTP associated with inflammation and cancer
4) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.27 Pain Relevance 0.34
It is not necessarily that TTP levels are reduced in order to observe reduced TTP-induced mRNA decay, since phosphorylation of TTP due to aberration in signaling pathways, such as overactivated p38 MAPK, is a defect that is observed in several cancers.
Negative_regulation (reduced) of Gene_expression (levels) of TTP associated with cancer
5) Confidence 0.04 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.85 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox