INT327246

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 2.48
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ttpa) transport (Ttpa) intracellular (Ttpa)
cytoplasm (Ttpa)
Ttpa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1044 99.32 Very High Very High Very High
Inflammatory stimuli 27 86.16 High High
cytokine 297 85.16 High High
cINOD 45 19.20 Low Low
chemokine 90 5.00 Very Low Very Low Very Low
Arthritis 45 5.00 Very Low Very Low Very Low
Inflammatory response 36 5.00 Very Low Very Low Very Low
Kinase C 36 5.00 Very Low Very Low Very Low
aspirin 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1080 99.32 Very High Very High Very High
Cancer 1296 96.96 Very High Very High Very High
Disease 81 77.36 Quite High
Congenital Anomalies 18 73.36 Quite High
Starvation 18 64.48 Quite High
Targeted Disruption 54 60.64 Quite High
Colon Cancer 72 15.16 Low Low
Hypoxia 99 5.00 Very Low Very Low Very Low
Metastasis 81 5.00 Very Low Very Low Very Low
Colitis 54 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The last group is heterogeneous and large and not necessarily functional while the key characteristic of other groups’ transcripts is the presence of the WWAUUUAUUUAWW sequence which likely RNA-binding proteins such as TTP could bind to, thus resulting in a large number of potential TTP and other RNA-binding protein mRNA targets [60].
TTP Binding (bind) of
1) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0 Pain Relevance 0
Further evidence of ARE functionality is from work on interactions of synthetic RNA molecules with TTP also showing that as small as UAUUUAU and UUAUUUAUU can bind TTP and that the 13-bp motif ARE has a strong affinity for TTP [45, 46].
TTP Binding (bind) of
2) Confidence 0.04 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0 Pain Relevance 0
The RNA-binding stabilizing protein, HuR, is able to compete with the RNA-binding proteins such as TTP and AUF1 for the same mRNA targets; however, it can also act independently on mRNA targets for promoting mRNA stabilization
TTP Binding (binding) of
3) Confidence 0.04 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.93 Pain Relevance 0.28
The RNA-binding stabilizing protein, HuR, is able to compete with the RNA-binding proteins such as TTP and AUF1 for the same mRNA targets; however, it can also act independently on mRNA targets for promoting mRNA stabilization
TTP Binding (proteins) of
4) Confidence 0.04 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.92 Pain Relevance 0.28
Well-established mRNA targets for TTP binding are involved in inflammation include the mRNAs of TNF-?
TTP Binding (binding) of associated with inflammation
5) Confidence 0.04 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.63 Pain Relevance 0.13
The adenylate residues in the pentamer (AUUUA)or hexamer (AUUUUA) core are important for TTP binding but not necessarily for Hu proteins, which unlike TTP, can bind a U-rich tract [44–46].
TTP Binding (bind) of
6) Confidence 0.04 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0 Pain Relevance 0
The adenylate residues in the pentamer (AUUUA)or hexamer (AUUUUA) core are important for TTP binding but not necessarily for Hu proteins, which unlike TTP, can bind a U-rich tract [44–46].
TTP Binding (binding) of
7) Confidence 0.03 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0 Pain Relevance 0
Further evidence of ARE functionality is from work on interactions of synthetic RNA molecules with TTP also showing that as small as UAUUUAU and UUAUUUAUU can bind TTP and that the 13-bp motif ARE has a strong affinity for TTP [45, 46].
TTP Binding (interactions) of
8) Confidence 0.03 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0 Pain Relevance 0
Further evidence of ARE functionality is from work on interactions of synthetic RNA molecules with TTP also showing that as small as UAUUUAU and UUAUUUAUU can bind TTP and that the 13-bp motif ARE has a strong affinity for TTP [45, 46].
TTP Binding (affinity) of
9) Confidence 0.03 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0 Pain Relevance 0

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