INT327268

Context Info Confidence 0.28 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.02 Pain Relevance 0.21

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)

Elavl1 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 4 91.60 Inflammation 116 85.12 cytokine 33 82.24 chemokine 10 5.00 cINOD 5 5.00 Arthritis 5 5.00 Inflammatory response 4 5.00 Inflammatory stimuli 3 5.00 aspirin 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Cancer 144 99.74 Breast Cancer 5 89.12 INFLAMMATION 120 85.12 Colon Cancer 8 34.64 Lung Cancer 2 30.84 Metastasis 9 29.64 Hyperplasia 5 18.60 Glioblastoma 1 11.32 Hypoxia 11 5.00 Disease 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Aberrations in the expression or activity of these kinases in cancer can lead to changes in HuR phosphorylation that favor cytoplasmic localization of HuR.

Regulation (changes) of Phosphorylation (phosphorylation) of HuR associated with cancer

1) Confidence 0.28 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.02 Pain Relevance 0.21

General Comments

This test has worked.