INT327270

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.86
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ttpa) transport (Ttpa) intracellular (Ttpa)
cytoplasm (Ttpa)
Ttpa (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 66 96.64 Very High Very High Very High
Inflammation 232 96.24 Very High Very High Very High
Inflammatory stimuli 6 69.36 Quite High
cINOD 10 30.68 Quite Low
Kinase C 8 22.04 Low Low
chemokine 20 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 288 99.28 Very High Very High Very High
INFLAMMATION 240 96.24 Very High Very High Very High
Hepatocellular Cancer 4 93.68 High High
Glioma 4 87.92 High High
Breast Cancer 10 69.64 Quite High
Congenital Anomalies 4 56.56 Quite High
Colon Cancer 16 26.64 Quite Low
Hypoxia 22 5.00 Very Low Very Low Very Low
Metastasis 18 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the ERK pathway is overactivated in cancer, it is thought that ERK activation results in phosphorylation of TTP, leading to an increase in TTP mRNA targets such as VEGF [72].
Positive_regulation (results) of Phosphorylation (phosphorylation) of TTP associated with cancer
1) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.91 Pain Relevance 0.05
One of those is the p38 MAPK pathway that leads to phosphorylation and inactivation of the activity of the RNA decay-promoting proteins such as TTP and KSRP.
Positive_regulation (leads) of Phosphorylation (phosphorylation) of TTP
2) Confidence 0.04 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.95 Pain Relevance 0.33

General Comments

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