INT327280

Context Info Confidence 0.23 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 3.30 Pain Relevance 0.66

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)

Elavl1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 132 99.42 Inflammation 464 99.22 Kinase C 16 90.48 Inflammatory stimuli 12 82.68 Arthritis 20 26.68 chemokine 40 5.00 cINOD 20 5.00 Inflammatory response 16 5.00 aspirin 4 5.00 Inflammatory mediators 4 5.00

Disease Link Frequency Relevance Heat Cancer 576 99.84 INFLAMMATION 480 99.22 Congenital Anomalies 8 96.44 Breast Cancer 20 82.96 Leukemia 8 79.52 Glioma 8 72.40 Colon Cancer 32 56.84 Lung Cancer 8 53.04 Metastasis 36 51.84 Stress 12 51.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Ectopic expression of HuR overcomes TTP-mediated destabilization of IL-3 mRNA and HuR mRNA in an ARE-dependent manner [69, 73].

Positive_regulation (destabilization) of HuR mRNA

1) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.45 Pain Relevance 0.19

Pro-inflammatory cytokines can reduce KSRP binding and enhance HuR binding to iNOS 3?

Positive_regulation (enhance) of HuR associated with inflammation and cytokine

2) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.55 Pain Relevance 0.21

Overexpression and cytoplasmic localization of stabilizing ARE binding proteins, notably HuR, with commitment functional loss of RNA decay-promoting proteins such as TTP can be associated with chronic inflammation and cancer.

Positive_regulation (stabilizing) of HuR associated with inflammation and cancer

3) Confidence 0.21 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.28 Pain Relevance 0.17

How is cytoplasmic localization of HuR promoted in tumor cells?

Positive_regulation (promoted) of HuR associated with cancer

4) Confidence 0.21 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.02 Pain Relevance 0.08

General Comments

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