INT327280

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.30
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)
Elavl1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 132 99.42 Very High Very High Very High
Inflammation 464 99.22 Very High Very High Very High
Kinase C 16 90.48 High High
Inflammatory stimuli 12 82.68 Quite High
Arthritis 20 26.68 Quite Low
chemokine 40 5.00 Very Low Very Low Very Low
cINOD 20 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 576 99.84 Very High Very High Very High
INFLAMMATION 480 99.22 Very High Very High Very High
Congenital Anomalies 8 96.44 Very High Very High Very High
Breast Cancer 20 82.96 Quite High
Leukemia 8 79.52 Quite High
Glioma 8 72.40 Quite High
Colon Cancer 32 56.84 Quite High
Lung Cancer 8 53.04 Quite High
Metastasis 36 51.84 Quite High
Stress 12 51.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ectopic expression of HuR overcomes TTP-mediated destabilization of IL-3 mRNA and HuR mRNA in an ARE-dependent manner [69, 73].
Positive_regulation (destabilization) of HuR mRNA
1) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.45 Pain Relevance 0.19
Pro-inflammatory cytokines can reduce KSRP binding and enhance HuR binding to iNOS 3?
Positive_regulation (enhance) of HuR associated with inflammation and cytokine
2) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.55 Pain Relevance 0.21
Overexpression and cytoplasmic localization of stabilizing ARE binding proteins, notably HuR, with commitment functional loss of RNA decay-promoting proteins such as TTP can be associated with chronic inflammation and cancer.
Positive_regulation (stabilizing) of HuR associated with inflammation and cancer
3) Confidence 0.21 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.28 Pain Relevance 0.17
How is cytoplasmic localization of HuR promoted in tumor cells?
Positive_regulation (promoted) of HuR associated with cancer
4) Confidence 0.21 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.02 Pain Relevance 0.08

General Comments

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