INT327285

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 4.72
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ttpa) transport (Ttpa) intracellular (Ttpa)
cytoplasm (Ttpa)
Anatomy Link Frequency
macrophages 1
Ttpa (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 264 96.28 Very High Very High Very High
Inflammation 928 95.88 Very High Very High Very High
Arthritis 40 81.72 Quite High
Inflammatory stimuli 24 69.36 Quite High
Inflammatory response 32 67.04 Quite High
chemokine 80 61.72 Quite High
Kinase C 32 41.88 Quite Low
cINOD 40 30.32 Quite Low
aspirin 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 16 99.80 Very High Very High Very High
Cancer 1152 99.06 Very High Very High Very High
INFLAMMATION 960 95.88 Very High Very High Very High
Hepatocellular Cancer 16 93.68 High High
Breast Cancer 40 89.48 High High
Disease 72 82.76 Quite High
Experimental Arthritis 8 81.72 Quite High
Targeted Disruption 48 80.24 Quite High
Congenital Anomalies 16 56.56 Quite High
Colon Cancer 64 26.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the ERK pathway is overactivated in cancer, it is thought that ERK activation results in phosphorylation of TTP, leading to an increase in TTP mRNA targets such as VEGF [72].
Phosphorylation (phosphorylation) of TTP associated with cancer
1) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.91 Pain Relevance 0.05
It is not necessarily that TTP levels are reduced in order to observe reduced TTP-induced mRNA decay, since phosphorylation of TTP due to aberration in signaling pathways, such as overactivated p38 MAPK, is a defect that is observed in several cancers.
Phosphorylation (phosphorylation) of TTP associated with cancer
2) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.86 Pain Relevance 0.13
An example is demonstrated with malignant gliomas in which TTP is hyperphosphorylated due most likely to p38 MAPK activation [163].
Phosphorylation (hyperphosphorylated) of TTP associated with glioma
3) Confidence 0.08 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.01 Pain Relevance 0.12
, IL-6, and IL-10 exclusively through TTP phosphorylation such as in murine bone marrow-derived macrophages [126].These above studies and others offer strong evidence for the p38 MAPK regulation of ARE-mRNA stability and the association with loss of TTP function.
Phosphorylation (phosphorylation) of TTP in macrophages
4) Confidence 0.08 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.32 Pain Relevance 0.11
In vitro evidence shows that TTP can be directly phosphorylated by either p38 or MK2 potentially modifying mRNA destabilizing activity of TTP [121, 122].
Phosphorylation (phosphorylated) of TTP
5) Confidence 0.08 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.31 Pain Relevance 0.13
Activation of the p38 MAPK pathway leads to MK2-mediated phosphorylation of TTP and KSRP leading to loss of function of these RNA-binding proteins, e.g., reduced affinity to ARE regions, and subsequently ARE-mRNA stabilization (Fig. 2) [122–124].
Phosphorylation (phosphorylation) of TTP
6) Confidence 0.07 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.23 Pain Relevance 0.21
The 14-3-3 proteins also protect RNA-binding proteins such as TTP from de-phosphorylation by the protein phosphatase 2?
Phosphorylation (phosphorylation) of TTP
7) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.14 Pain Relevance 0.07
One of those is the p38 MAPK pathway that leads to phosphorylation and inactivation of the activity of the RNA decay-promoting proteins such as TTP and KSRP.
Phosphorylation (phosphorylation) of TTP
8) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.95 Pain Relevance 0.33

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