INT327287

Context Info Confidence 0.31 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 2.11 Pain Relevance 0.64

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)

Elavl1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 348 99.12 Kinase C 12 57.48 cytokine 99 46.84 chemokine 30 5.00 cINOD 15 5.00 Arthritis 15 5.00 Inflammatory response 12 5.00 Inflammatory stimuli 9 5.00 aspirin 3 5.00 Inflammatory mediators 3 5.00

Disease Link Frequency Relevance Heat Cancer 432 99.34 INFLAMMATION 360 99.12 Hypoxia 33 5.00 Metastasis 27 5.00 Disease 27 5.00 Colon Cancer 24 5.00 Colitis 18 5.00 Targeted Disruption 18 5.00 Hyperplasia 15 5.00 Breast Cancer 15 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

B activity during chronic inflammation and cancer may be associated with elevated HuR transcription, and, subsequently, higher HuR-mediated stabilizing effects on target mRNAs.

Transcription (transcription) of HuR associated with inflammation and cancer

1) Confidence 0.31 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.72 Pain Relevance 0.20

Increased transcription of HuR may be mediated by a putative NF-?

Transcription (transcription) of HuR

2) Confidence 0.31 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.67 Pain Relevance 0.24

B activity during chronic inflammation and cancer may be associated with elevated HuR transcription, and, subsequently, higher HuR-mediated stabilizing effects on target mRNAs.

Transcription (transcription) of HuR associated with inflammation and cancer

3) Confidence 0.31 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.73 Pain Relevance 0.20

General Comments

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