INT327308

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.73
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Elavl1, Ttpa) cytosol (Ttpa) transport (Ttpa)
RNA binding (Elavl1) intracellular (Ttpa) nucleus (Elavl1)
Elavl1 (Mus musculus)
Ttpa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 232 99.44 Very High Very High Very High
Arthritis 10 63.88 Quite High
cytokine 66 56.48 Quite High
chemokine 20 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
Inflammatory stimuli 6 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 240 99.44 Very High Very High Very High
Cancer 288 98.76 Very High Very High Very High
Congenital Anomalies 4 94.72 High High
Leukemia 4 77.80 Quite High
Glioma 4 70.68 Quite High
Disease 18 64.92 Quite High
Experimental Arthritis 2 63.88 Quite High
Targeted Disruption 12 62.40 Quite High
Stress 6 49.56 Quite Low
Apoptosis 8 48.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The p38 MAPK may also phosphorylate ARE-stabilizing proteins such as HuR which could compete with the destabilizing proteins such as TTP as suggested in studies on the regulation of IL-3 mRNA decay [127].
HuR Binding (compete) of TTP
1) Confidence 0.02 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.42 Pain Relevance 0.13
Overexpression and cytoplasmic localization of stabilizing ARE binding proteins, notably HuR, with commitment functional loss of RNA decay-promoting proteins such as TTP can be associated with chronic inflammation and cancer.
HuR Binding (associated) of TTP associated with inflammation and cancer
2) Confidence 0.02 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.31 Pain Relevance 0.21

General Comments

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