INT327313

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mapk14, Khsrp) nucleus (Mapk14, Khsrp) transport (Khsrp)
mitochondrion (Mapk14) cell morphogenesis (Mapk14) DNA binding (Khsrp)
Mapk14 (Mus musculus)
Khsrp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 33 72.76 Quite High
Inflammatory response 4 69.32 Quite High
chemokine 10 64.00 Quite High
Inflammation 116 59.76 Quite High
Arthritis 5 25.60 Quite Low
Inflammatory stimuli 3 15.64 Low Low
cINOD 5 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 120 68.92 Quite High
Cancer 144 53.84 Quite High
Targeted Disruption 6 28.48 Quite Low
Experimental Arthritis 1 26.32 Quite Low
Disease 9 23.36 Low Low
Congenital Anomalies 2 21.76 Low Low
Hypoxia 11 5.00 Very Low Very Low Very Low
Metastasis 9 5.00 Very Low Very Low Very Low
Colon Cancer 8 5.00 Very Low Very Low Very Low
Colitis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the p38 MAPK pathway leads to MK2-mediated phosphorylation of TTP and KSRP leading to loss of function of these RNA-binding proteins, e.g., reduced affinity to ARE regions, and subsequently ARE-mRNA stabilization (Fig. 2) [122–124].
Positive_regulation (Activation) of p38 MAPK Positive_regulation (leads) of Phosphorylation (phosphorylation) of KSRP
1) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.24 Pain Relevance 0.22

General Comments

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