INT327318

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.42 Pain Relevance 0.13

cytoplasm (Mapk14, Elavl1) nucleus (Mapk14, Elavl1) mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14) cytosol (Mapk14)

Mapk14 (Mus musculus) Elavl1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 116 97.44 Arthritis 5 58.28 cytokine 33 50.88 chemokine 10 5.00 cINOD 5 5.00 Inflammatory response 4 5.00 Kinase C 4 5.00 Inflammatory stimuli 3 5.00 aspirin 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 120 97.44 Cancer 144 96.76 Disease 9 59.32 Experimental Arthritis 1 58.28 Targeted Disruption 6 56.80 Hypoxia 11 5.00 Metastasis 9 5.00 Colon Cancer 8 5.00 Colitis 6 5.00 Hyperplasia 5 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The p38 MAPK regulates HuR localization and subsequently HuR mRNA targets that are involved in chronic inflammation and cancer such as uPA and COX-2 [128–130].

p38 MAPK Regulation (regulates) of Localization (localization) of HuR associated with inflammation and cancer

1) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.42 Pain Relevance 0.13

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