INT327338

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.93
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mapk1, VEGFA) nucleoplasm (Mapk1) mitochondrion (Mapk1)
protein complex (Mapk1) cytosol (Mapk1) extracellular space (VEGFA)
Mapk1 (Mus musculus)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 116 95.96 Very High Very High Very High
cytokine 33 41.48 Quite Low
Kinase C 4 22.64 Low Low
chemokine 10 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 144 99.58 Very High Very High Very High
Hepatocellular Cancer 2 98.24 Very High Very High Very High
INFLAMMATION 120 95.96 Very High Very High Very High
Glioma 2 88.52 High High
Breast Cancer 5 70.24 Quite High
Chronic Disease 1 5.68 Low Low
Hypoxia 11 5.00 Very Low Very Low Very Low
Metastasis 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Colon Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the ERK pathway is overactivated in cancer, it is thought that ERK activation results in phosphorylation of TTP, leading to an increase in TTP mRNA targets such as VEGF [72].
Positive_regulation (activation) of ERK Positive_regulation (leading) of Positive_regulation (increase) of VEGF associated with cancer
1) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.93 Pain Relevance 0.05

General Comments

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