INT32736

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Context Info
Confidence 0.26
First Reported 1985
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.35
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi) carbohydrate metabolic process (Gpi) cytoplasm (Gpi)
cytosol (Gpi) extracellular space (Gpi) extracellular region (Gpi)
Anatomy Link Frequency
neurons 1
median eminence 1
MVD 1
HbL 1
Gpi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 1 99.04 Very High Very High Very High
midbrain 5 98.32 Very High Very High Very High
Dopamine 33 97.80 Very High Very High Very High
agonist 6 94.88 High High
Central nervous system 3 94.64 High High
Thalamus 11 84.04 Quite High
Enkephalin 12 75.00 Quite High
Pain 2 73.12 Quite High
Potency 1 61.12 Quite High
cerebral cortex 5 56.88 Quite High
Disease Link Frequency Relevance Heat
Dyskinesias 1 99.76 Very High Very High Very High
Movement Disorders 2 95.80 Very High Very High Very High
Nociception 2 95.36 Very High Very High Very High
Disease 26 94.04 High High
Sleep Disorders 26 92.88 High High
Pain 2 73.12 Quite High
Parkinson's Disease 7 68.96 Quite High
Glioma 1 68.48 Quite High
Neuroblastoma 1 68.20 Quite High
Generalized Anxiety Disorder 2 18.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction between CM-Pf, HbL, GPi, STN and SNC might provide a new template for high frequency stimulation strategies in the treatment of movement disorders.
GPi Spec (might) Binding (interaction) of in HbL associated with movement disorders
1) Confidence 0.26 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 18812212 Disease Relevance 0.52 Pain Relevance 0.12
Special attention was focused on possible cross-reactivity between PHI antisera and corticotropin releasing factor in parvocellular neurons in the hypothalamic paraventricular nucleus projecting to the external layer of the median eminence. (1) Characterization of the PHI and VIP antisera revealed that they recognized different sequences of the peptide molecules.
PHI antisera Binding (cross-reactivity) of in median eminence
2) Confidence 0.17 Published 1987 Journal Neuroscience Section Abstract Doc Link 3125490 Disease Relevance 0 Pain Relevance 0.16
The major source of dopamine in the BG is the midbrain dopaminergic neurons, particularly the SNc (A9 group), and these neurons primarily target the striatum, GPe and GPi.
GPi Binding (target) of in neurons associated with dopamine and midbrain
3) Confidence 0.08 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2996256 Disease Relevance 0.69 Pain Relevance 0.44
Two selected dimers and their corresponding monomers were also assayed for antinociceptive activity in vivo: results were consistent with GPI and mu-binding but not with MVD and delta-binding.
GPI Neg (not) Binding (binding) of in MVD associated with antinociceptive
4) Confidence 0.05 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 2981528 Disease Relevance 0.14 Pain Relevance 0.32

General Comments

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