INT327363

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 8.21
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ttr) extracellular space (Ttr) extracellular region (Ttr)
Anatomy Link Frequency
blood 2
peripheral nerve 2
neural 2
Ttr (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 54 87.36 High High
Inflammation 73 85.44 High High
cytokine 9 84.40 Quite High
metalloproteinase 35 73.56 Quite High
Pain 7 73.52 Quite High
Spinal cord 7 65.76 Quite High
Peripheral nervous system 14 62.56 Quite High
unmyelinated 7 61.60 Quite High
alcohol 11 28.32 Quite Low
depression 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 236 99.92 Very High Very High Very High
Familial Amyloidotic Polyneuropathy 147 99.48 Very High Very High Very High
Disease 359 99.42 Very High Very High Very High
Amyloid Plaque 100 97.84 Very High Very High Very High
Shock 14 96.84 Very High Very High Very High
Targeted Disruption 110 96.42 Very High Very High Very High
Death 32 95.00 High High
Stress 151 94.24 High High
Apoptosis 28 89.60 High High
INFLAMMATION 77 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Above all, it was necessary to assess extracellular deposition of TTR by immunohistochemistry in organs most affected with deposition.
Negative_regulation (deposition) of TTR
1) Confidence 0.40 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.53 Pain Relevance 0
Most importantly, TUDCA treatment significantly reduced TTR toxic aggregates in as much as 75% [12].
Negative_regulation (reduced) of TTR
2) Confidence 0.40 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.10 Pain Relevance 0.07
Familial Amyloid Polyneuropathy (FAP) is characterized by the deposition of Transthyretin (TTR) amyloid fibrils in several organs, with special involvement of the peripheral nerve.
Negative_regulation (deposition) of Transthyretin in peripheral nerve associated with familial amyloidotic polyneuropathy and alzheimer's dementia
3) Confidence 0.40 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.09 Pain Relevance 0.10
Familial Amyloid Polyneuropathy (FAP) is characterized by the deposition of Transthyretin (TTR) amyloid fibrils in several organs, with special involvement of the peripheral nerve.
Negative_regulation (deposition) of TTR in peripheral nerve associated with familial amyloidotic polyneuropathy and alzheimer's dementia
4) Confidence 0.40 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.09 Pain Relevance 0.10
The decrease in TTR deposition and associated biomarkers was not as impressive in the lower dosages, which are equivalent to a clinical setting, as compared to the higher doses, indicating a dose response behavior that is still efficient.



Negative_regulation (decrease) of TTR
5) Confidence 0.35 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.29 Pain Relevance 0
Very recently, another FAP mouse model was generated, the V30M transgenic mice in a heat shock factor 1 (HSF-1) null background, representing a step forward in the study of this disorder; these mice represent an improved FAP model since animals showed TTR deposition in extra-neural and neural tissues, and recapitulated pathological findings in FAP.
Negative_regulation (deposition) of TTR in neural associated with targeted disruption, familial amyloidotic polyneuropathy and shock
6) Confidence 0.35 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.26 Pain Relevance 0.23
Interestingly, AD patients show a significant decrease in CSF transthyretin levels [159] while decreased transthyretin levels have also been found in blood serum of long-term wireless phone users [158].
Negative_regulation (decreased) of transthyretin in blood associated with disease
7) Confidence 0.18 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.79 Pain Relevance 0.04
Interestingly, AD patients show a significant decrease in CSF transthyretin levels [159] while decreased transthyretin levels have also been found in blood serum of long-term wireless phone users [158].
Negative_regulation (decrease) of transthyretin in blood associated with disease
8) Confidence 0.16 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.80 Pain Relevance 0.04
Very recently, another FAP mouse model was generated, the V30M transgenic mice in a heat shock factor 1 (HSF-1) null background, representing a step forward in the study of this disorder; these mice represent an improved FAP model since animals showed TTR deposition in extra-neural and neural tissues, and recapitulated pathological findings in FAP.
Negative_regulation (deposition) of TTR in neural associated with targeted disruption, familial amyloidotic polyneuropathy and shock
9) Confidence 0.12 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.26 Pain Relevance 0.23

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