INT327364

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.94
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ttr) extracellular space (Ttr) extracellular region (Ttr)
Ttr (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 10 31.60 Quite Low
Inflammation 18 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Amyloidotic Polyneuropathy 42 98.92 Very High Very High Very High
Death 8 88.20 High High
Stress 22 87.44 High High
Alzheimer's Dementia 64 70.88 Quite High
Amyloidosis 2 61.48 Quite High
Disease 14 54.68 Quite High
Amyloid Plaque 24 37.76 Quite Low
Targeted Disruption 16 30.08 Quite Low
Apoptosis 8 10.56 Low Low
INFLAMMATION 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 3 displays representative images of the results obtained and clearly shows that TTR deposition is significantly decreased in mice submitted to the high doxycycline/TUDCA dose combined treatment.
Negative_regulation (decreased) of Gene_expression (deposition) of TTR
1) Confidence 0.40 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.48 Pain Relevance 0
As TUDCA is effective in reducing TTR load in young TTR mice, in this work we also explored the potential of two drugs, doxycycline and TUDCA, and found a synergistic effect as combined cycled administration of both drugs was clearly beneficial to lower TTR deposition and all the biomarkers under study, whereas single individual drug administration failed to produce improvement of all of the markers evaluated.
Negative_regulation (reducing) of Gene_expression (load) of TTR
2) Confidence 0.35 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.46 Pain Relevance 0

General Comments

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