INT327376

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.91
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
embryos 2
uterine muscle 2
lung 2
Oxtr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 184 99.98 Very High Very High Very High
Dismenorea 25 90.72 High High
Neuropeptide 8 89.52 High High
bradykinin 40 87.04 High High
Inflammation 113 83.04 Quite High
antagonist 33 79.04 Quite High
agonist 81 64.56 Quite High
corticosteroid 16 42.08 Quite Low
Inflammatory mediators 8 18.24 Low Low
depression 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 24 98.32 Very High Very High Very High
Cancer 32 97.96 Very High Very High Very High
Asthma 272 92.52 High High
Dysmenorrhea 25 90.72 High High
INFLAMMATION 121 83.04 Quite High
Obesity 11 76.96 Quite High
Acute-phase Reaction 8 63.76 Quite High
Injury 16 60.96 Quite High
Pulmonary Disease 8 57.36 Quite High
Stress 80 54.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 2, expression of oxytocin receptor was significantly augmented in cells treated with either TNF?
Positive_regulation (augmented) of Gene_expression (expression) of oxytocin receptor
1) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.27 Pain Relevance 0.19
Cytokines increase oxytocin receptor expression in HASMCs
Positive_regulation (increase) of Gene_expression (expression) of oxytocin receptor associated with cytokine
2) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.20 Pain Relevance 0.11
was more effective in increasing oxytocin receptor expression, oxytocin had no modulating effect on oxytocin-induced calcium responses in HASM cells.
Positive_regulation (increasing) of Gene_expression (expression) of oxytocin receptor
3) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.15 Pain Relevance 0.24
These data suggest that OXTR expression in lung occurs at low levels in the basal state (Table 1).


Positive_regulation (occurs) of Gene_expression (expression) of OXTR in lung
4) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.20 Pain Relevance 0.07
Using these models, investigators found that OXTR expression was downregulated by IL-1?
Positive_regulation (by) of Gene_expression (expression) of OXTR
5) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.61 Pain Relevance 0.26
increased expression of oxytocin receptor by approximately 5 fold at 6 hr and 7 fold at 18 hr as compared with that obtained from diluent-treated cells (Figure 1B).
Positive_regulation (increased) of Gene_expression (expression) of oxytocin receptor
6) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.19 Pain Relevance 0.09
stimulate a time-dependent increase in OXTR expression at 6 and 18 hr.
Positive_regulation (increase) of Gene_expression (expression) of OXTR
7) Confidence 0.38 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2922094 Disease Relevance 0.60 Pain Relevance 0.16
Immunocytochemistry of mouse embryos (embryonic day 15) showed cardiac OT-GKR accumulation and OTR expression.
Positive_regulation (accumulation) of Gene_expression (expression) of OTR in embryos
8) Confidence 0.34 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0.08
Prior to the onset of labor, uterine muscle becomes exquisitely sensitive to oxytocin due to dramatic increases in the expression of oxytocin receptors (OXTR) [2] whose activation promotes myometrial shortening.
Positive_regulation (increases) of Gene_expression (expression) of OXTR in uterine muscle
9) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.65 Pain Relevance 0.18
The Oxtr predominantly signals via Gq/11 but is a promiscuous receptor in that it may signal through a variety of different ?
Positive_regulation (via) of Gene_expression (signals) of Oxtr
10) Confidence 0.32 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.05 Pain Relevance 0

General Comments

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