INT327386

Context Info Confidence 0.20 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.98 Pain Relevance 0.45

signal transduction (TNF, Oxtr) extracellular space (TNF) extracellular region (TNF) plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)

Anatomy Link Frequency smooth muscle 2 TNF (Homo sapiens) Oxtr (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 46 100.00 Inflammation 28 100.00 bradykinin 10 85.60 agonist 18 84.32 Inflammatory mediators 2 18.72 Dismenorea 6 5.00 corticosteroid 4 5.00 Neuropeptide 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 30 100.00 Asthma 68 91.92 Necrosis 6 71.00 Cancer 8 70.64 Disease 8 57.56 Pyelonephritis 2 52.84 Increased Venous Pressure Under Development 2 51.92 Myocardial Infarction 2 51.04 Respiratory Disease 2 20.08 Nicotine Addiction 4 12.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Real time PCR was performed to assess whether oxytocin receptor expression was modulated by pro-inflammatory cytokines, TNF?

TNF Spec (whether) Regulation (modulated) of Spec (whether) Gene_expression (expression) of oxytocin receptor associated with inflammation and cytokine

1) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.10 Pain Relevance 0.10

Here, we report the expression and function of oxytocin receptor in airway smooth muscle (both in human and mouse); more importantly, we also report that oxytocin receptor expression is affected by IL-13 and TNF?.

TNF Regulation (affected) of Gene_expression (expression) of oxytocin receptor in smooth muscle

2) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.88 Pain Relevance 0.35

General Comments

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