INT327394

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.62
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Siva1) mitochondrion (Siva1) nucleus (Siva1)
cytoplasm (Siva1)
Siva1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 2 60.00 Quite High
metalloproteinase 7 51.36 Quite High
antagonist 15 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 25 100.00 Very High Very High Very High
Stress 4 99.92 Very High Very High Very High
Cancer 146 83.80 Quite High
Metastasis 60 78.80 Quite High
Death 5 72.60 Quite High
Severe Combined Immunodeficiency 11 69.64 Quite High
Ovarian Cancer 16 68.60 Quite High
Toxicity 3 62.48 Quite High
Head & Neck Cancer 6 52.88 Quite High
Squamous Cell Carcinoma 9 48.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Siva-1 has also been shown to bind and sequester the anti-apoptotic BCL-XL protein and promote the progression of apoptosis via the mithochondrial pathway.
Siva-1 Binding (bind) of associated with apoptosis
1) Confidence 0.04 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.67 Pain Relevance 0.05
SOD protects cells from oxidative stress by catalyzing the disproportionation of superoxide to hydrogen peroxide [47], whereas XIAP protein modulates oxidative stress by binding to apoptosis-inducing factor (AIF) [46].
apoptosis-inducing factor Binding (binding) of associated with stress and apoptosis
2) Confidence 0.02 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.94 Pain Relevance 0.03

General Comments

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