INT327399

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.75
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) plasma membrane (Ptk2)
cytoskeleton (Ptk2) nucleus (Ptk2) extracellular matrix organization (Ptk2)
Ptk2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 42 98.84 Very High Very High Very High
metalloproteinase 13 83.52 Quite High
depression 4 30.36 Quite Low
imagery 20 5.00 Very Low Very Low Very Low
cytokine 15 5.00 Very Low Very Low Very Low
Bioavailability 8 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
fortral 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 95 100.00 Very High Very High Very High
Cancer 557 99.62 Very High Very High Very High
Apoptosis 180 97.52 Very High Very High Very High
Metastasis 250 77.24 Quite High
Melanoma 63 50.00 Quite Low
Colon Cancer 50 50.00 Quite Low
Head & Neck Cancer 24 50.00 Quite Low
Severe Combined Immunodeficiency 48 44.84 Quite Low
Squamous Cell Carcinoma 36 40.36 Quite Low
Carcinoma 52 32.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, TM also inhibited the activation of focal adhesion kinase (FAK), an important cell migration mediator (Fig. 4D).
Negative_regulation (inhibited) of Positive_regulation (activation) of FAK associated with adhesions
1) Confidence 0.43 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.87 Pain Relevance 0
TM treatment significantly inhibited FAK activation as well as the activation of LOX.
Negative_regulation (inhibited) of Positive_regulation (activation) of FAK
2) Confidence 0.43 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.20 Pain Relevance 0
Therefore, TM may be inhibiting tumor cell migration by inhibiting FAK activation via lysyl oxidase.
Negative_regulation (inhibiting) of Positive_regulation (activation) of FAK associated with cancer
3) Confidence 0.31 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.02 Pain Relevance 0.04
In addition, TM also inhibited the activation of focal adhesion kinase (FAK), an important cell migration mediator (Fig. 4D).
Negative_regulation (inhibited) of Positive_regulation (activation) of adhesion kinase associated with adhesions
4) Confidence 0.27 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.87 Pain Relevance 0
Interestingly, decreased FAK activation and protein levels preceded the alterations in Mcl-1 and Bim levels (Figure 4D).
Negative_regulation (decreased) of Positive_regulation (activation) of FAK
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.31 Pain Relevance 0.05
Analysis of adherent HT29 cells confirmed that loss of FAK activation preceded decay in Mcl-1 protein levels (Figure 4F) observed in cells in suspension (Figure 4D).
Negative_regulation (loss) of Positive_regulation (activation) of FAK
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.39 Pain Relevance 0.04
The parental anti-MCSP mAb 9.2.27 has been shown to prevent association of MCSP with integrins, thereby preventing activation of FAK [6].
Negative_regulation (preventing) of Positive_regulation (activation) of FAK
7) Confidence 0.18 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.10 Pain Relevance 0

General Comments

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