INT32747

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Context Info
Confidence 0.16
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.92
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Avp, Pomc) signal transduction (Avp, Pomc) extracellular region (Avp, Pomc)
cell-cell signaling (Pomc) cytoplasm (Pomc) response to stress (Avp)
Anatomy Link Frequency
pituitary 2
corticotrophs 2
Avp (Rattus norvegicus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 84 99.74 Very High Very High Very High
corticosteroid 6 98.96 Very High Very High Very High
Inflammation 54 97.20 Very High Very High Very High
medulla 5 84.96 Quite High
Catecholamine 3 81.76 Quite High
Morphine 3 72.68 Quite High
Deafferentation 2 63.56 Quite High
Action potential 2 51.72 Quite High
Potency 2 35.08 Quite Low
agonist 44 34.40 Quite Low
Disease Link Frequency Relevance Heat
Stress 120 100.00 Very High Very High Very High
INFLAMMATION 56 97.20 Very High Very High Very High
Targeted Disruption 44 93.84 High High
Hyperplasia 12 35.40 Quite Low
Cancer 44 5.00 Very Low Very Low Very Low
Pituitary Cancer 22 5.00 Very Low Very Low Very Low
Starvation 20 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 16 5.00 Very Low Very Low Very Low
Natriuresis 14 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to corticotropin-releasing factor (CRF) and structurally related peptides, arginine vasopressin (AVP), oxytocin, angiotensin II, vasoactive intestinal polypeptide, peptide histidine isoleucinamide, epinephrine (E), and norepinephrine induce secretion of adrenocorticotropin (ACTH) from corticotropic cells in vitro.
AVP Positive_regulation (induce) of Localization (secretion) of ACTH
1) Confidence 0.16 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 2981737 Disease Relevance 0.14 Pain Relevance 0.04
Studies of the role of AVP in pituitary-adrenal control by the use of pressor receptor (V1) antagonists are not valuable because of the ineffectiveness of such antagonists in blocking AVP-induced release of ACTH from corticotropic cells in vitro.
AVP-induced Positive_regulation (induced) of Localization (release) of ACTH in pituitary associated with antagonist
2) Confidence 0.15 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 2981737 Disease Relevance 0.65 Pain Relevance 0.24
In addition to corticotropin-releasing factor (CRF) and structurally related peptides, arginine vasopressin (AVP), oxytocin, angiotensin II, vasoactive intestinal polypeptide, peptide histidine isoleucinamide, epinephrine (E), and norepinephrine induce secretion of adrenocorticotropin (ACTH) from corticotropic cells in vitro.
vasopressin Positive_regulation (induce) of Localization (secretion) of ACTH
3) Confidence 0.14 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 2981737 Disease Relevance 0.14 Pain Relevance 0.04
In the latter mice, basal ACTH secretion and the stress response is mediated by AVP but the rise in ACTH and corticosteroid secretion was preserved even after immunoneutralisation of AVP in the latter CRH-R1-null mice (567).
AVP Positive_regulation (mediated) of Localization (secretion) of ACTH associated with stress and corticosteroid
4) Confidence 0.06 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.64 Pain Relevance 0.26
In addition, AVP enhances the responsiveness of corticotrophs to CRH in terms of ACTH secretion (565) but not in terms of POMC gene transcription (566).
AVP Positive_regulation (enhances) of Localization (secretion) of ACTH in corticotrophs
5) Confidence 0.05 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.35 Pain Relevance 0.03

General Comments

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