INT3275

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Context Info
Confidence 0.37
First Reported 1978
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 28
Total Number 31
Disease Relevance 10.93
Pain Relevance 5.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slco1c1)
Anatomy Link Frequency
brain 9
cavity 2
plasma 1
cerebral hemisphere 1
spinal cord 1
Slco1c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 5 99.76 Very High Very High Very High
Spinal cord 126 99.62 Very High Very High Very High
Central nervous system 131 99.30 Very High Very High Very High
Sumatriptan 10 97.56 Very High Very High Very High
ischemia 41 97.12 Very High Very High Very High
Migraine 4 95.60 Very High Very High Very High
Neuropathic pain 1 95.28 Very High Very High Very High
c fibre 168 92.12 High High
Peripheral nerve injury 104 92.08 High High
Pain 7 91.08 High High
Disease Link Frequency Relevance Heat
Frailty 2 99.76 Very High Very High Very High
Recurrence 16 99.20 Very High Very High Very High
Injury 192 99.08 Very High Very High Very High
Pressure And Volume Under Development 118 99.04 Very High Very High Very High
Cancer 352 98.98 Very High Very High Very High
Disease 7 98.72 Very High Very High Very High
Increased Venous Pressure Under Development 13 98.38 Very High Very High Very High
Brain Disease 4 98.24 Very High Very High Very High
Brain Tumor 26 98.04 Very High Very High Very High
Demyelinating Disease 7 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Halothane appears to inhibit BBB glucose transport by competing for the glucose carrier and by altering the affinity of the carrier for glucose, perhaps by altering the environment of the carrier or the carrier itself.
Spec (appears) Negative_regulation (inhibit) of BBB associated with halothane
1) Confidence 0.37 Published 1978 Journal Anesthesiology Section Abstract Doc Link 686438 Disease Relevance 0 Pain Relevance 0.29
Implications: When the blood-brain barrier (BBB) was disrupted by a hyperosmolar solution, pentobarbital attenuated the degree of leakage of the BBB.
Negative_regulation (disrupted) of BBB in brain
2) Confidence 0.37 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620510 Disease Relevance 0.09 Pain Relevance 0
This study was performed to evaluate both the effects of pentobarbital on disruption of the blood-brain barrier (BBB) by hyperosmolar mannitol and the relationship between its effect on blood pressure and the integrity of the BBB.
Negative_regulation (disruption) of BBB in brain
3) Confidence 0.37 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620510 Disease Relevance 0 Pain Relevance 0.13
Our study suggests that when the BBB is disrupted, pentobarbital may be effective in protecting the BBB.
Negative_regulation (disrupted) of BBB
4) Confidence 0.37 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620510 Disease Relevance 0.10 Pain Relevance 0
This study was performed to evaluate both the effects of pentobarbital on disruption of the blood-brain barrier (BBB) by hyperosmolar mannitol and the relationship between its effect on blood pressure and the integrity of the BBB.
Negative_regulation (disruption) of blood-brain barrier in brain
5) Confidence 0.37 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620510 Disease Relevance 0 Pain Relevance 0.13
Implications: When the blood-brain barrier (BBB) was disrupted by a hyperosmolar solution, pentobarbital attenuated the degree of leakage of the BBB.
Negative_regulation (disrupted) of blood-brain barrier in brain
6) Confidence 0.37 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620510 Disease Relevance 0.09 Pain Relevance 0
Magnesium administration attenuated the increased BBB permeability defect and caused a reduction in brain edema formation in our rat model of intraperitoneal sepsis.



Negative_regulation (defect) of BBB in brain associated with pressure and volume under development and sepsis
7) Confidence 0.29 Published 2005 Journal Crit Care Section Abstract Doc Link PMC1065104 Disease Relevance 0.51 Pain Relevance 0
In the S-Mg group, BBB permeability was significantly decreased in comparison with the S group (Table 2).
Negative_regulation (decreased) of BBB
8) Confidence 0.29 Published 2005 Journal Crit Care Section Body Doc Link PMC1065104 Disease Relevance 0.83 Pain Relevance 0
These observations in TBI demonstrate that early intervention with Cerebrolysin reduces BBB and BCSFB permeability changes, attenuates brain pathology and brain edema, and mitigates functional deficits.
Negative_regulation (reduces) of BBB in brain associated with pressure and volume under development and brain disease
9) Confidence 0.07 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20633118 Disease Relevance 0.69 Pain Relevance 0.17
In conclusion, L-NAME worsened BBB disruption induced by hyperosmolar solution, which may be due to the pressure effect of L-NAME.
Negative_regulation (disruption) of BBB
10) Confidence 0.04 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9024031 Disease Relevance 0 Pain Relevance 0
A possible explanation for this would be that mannitol leaks through the disrupted BBB continuously and accumulates in the brain parenchyma, so that the osmotic pressure gradient inside and outside of the BBB is decreased or even reversed.
Negative_regulation (decreased) of BBB in parenchyma
11) Confidence 0.04 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3004923 Disease Relevance 0.57 Pain Relevance 0.05
Kaufmann and Cardoso [40] and Cho et al [41] reported that mannitol accumulated constantly in the injured cerebral hemisphere when it was used repeatedly by the intravenous route, so that the osmotic pressure gradient inside and outside the BBB is reversed, thus exacerbating the cerebral edema.
Negative_regulation (reversed) of BBB in cerebral hemisphere associated with pressure and volume under development
12) Confidence 0.04 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3004923 Disease Relevance 0.71 Pain Relevance 0.08
Sumatriptan (1000 micrograms kg-1), known to be poorly brain penetrant, had no significant effect on c-fos mRNA expression in the NtV unless the BBB was disrupted by infusion of a hyperosmolar mannitol solution after which sumatriptan decreased c-fos mRNA expression by 65 +/- 11%.
Negative_regulation (disrupted) of BBB in brain associated with sumatriptan
13) Confidence 0.03 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7630480 Disease Relevance 0.30 Pain Relevance 0.77
Furthermore the data indicates that the anti-migraine action of sumatriptan must be predominantly peripherally mediated, be it via inhibition of plasma extravasation or direct vasoconstriction, since it had little effect on the activation of neurones in the NtV unless the BBB was disrupted.
Negative_regulation (disrupted) of BBB in plasma associated with sumatriptan, migraine and increased venous pressure under development
14) Confidence 0.03 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7630480 Disease Relevance 0.37 Pain Relevance 0.69
Traumatic and ischemic injuries to the CNS are well-known to cause localized disruption of the BBB which is considered critical to the pathophysiology [1,33,34].
Negative_regulation (disruption) of BBB associated with injury and central nervous system
15) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 1.17 Pain Relevance 0.55
A final, and much more speculative, possibility to consider pertains to non-traumatic, non-ischemic disorders where disruption of the BBB appears critical for the pathophysiology, such as demyelinating, neuroimmune or neurodegenerative disorders.
Negative_regulation (disruption) of BBB associated with neurodegenerative disease and demyelinating disease
16) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0.82 Pain Relevance 0.51
In addition, or alternatively, to increased production of certain gene products, key elements of the BBB might become reduced, and in preliminary experiments we have found a decrease in the level of aquaporin-4, a component of the BBB, preceding the increase in permeability [19].
Negative_regulation (decrease) of BBB
17) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0 Pain Relevance 0.40
In addition, or alternatively, to increased production of certain gene products, key elements of the BBB might become reduced, and in preliminary experiments we have found a decrease in the level of aquaporin-4, a component of the BBB, preceding the increase in permeability [19].
Negative_regulation (reduced) of BBB
18) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0 Pain Relevance 0.40
Recently, it has been shown that focused ultrasound in the presence of circulatory microbubbles (ultrasound contrast agent) is able to locally and temporarily disrupt the BBB, providing a potential and promising method for drug delivery [11,12,15].
Negative_regulation (disrupt) of BBB
19) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0.04
The BBB was disrupted in two four-spot lines (1-1.5 mm spacing) along the right hemisphere of rat brain with ultrasound beams (0.3 MPa, 120 s, 10 ms bursts, repetition frequency = 1 Hz) in the presence Definity microbubbles.
Negative_regulation (disrupted) of BBB in brain
20) Confidence 0.02 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0.03

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