INT32753

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Context Info
Confidence 0.62
First Reported 1985
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 19
Total Number 26
Disease Relevance 3.30
Pain Relevance 16.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
paw 4
neuronal 2
erythrocytes 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 982 100.00 Very High Very High Very High
Opioid 169 100.00 Very High Very High Very High
agonist 94 100.00 Very High Very High Very High
Morphine 69 100.00 Very High Very High Very High
mu opioid receptor 25 100.00 Very High Very High Very High
opiate 14 100.00 Very High Very High Very High
methadone 2 99.72 Very High Very High Very High
Pain 90 99.14 Very High Very High Very High
narcan 23 99.14 Very High Very High Very High
antagonist 245 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

192 99.04 Very High Very High Very High
Anaemia 1 98.56 Very High Very High Very High
Nociception 45 98.44 Very High Very High Very High
Pheochromocytoma 13 92.64 High High
Infection 4 89.60 High High
Neuroblastoma 9 89.16 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 89.16 High High
Neurological Disease 4 87.68 High High
INFLAMMATION 9 83.64 Quite High
Mental Disorders 1 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PHA stimulation increased activation of the MOR promoter as well as levels of MOR mRNA, total receptor protein in cell lysates, and surface and cytoplasmic receptor expression.
Positive_regulation (increased) of Positive_regulation (activation) of MOR associated with mu opioid receptor
1) Confidence 0.62 Published 2005 Journal J. Neurovirol. Section Abstract Doc Link 16036794 Disease Relevance 0.36 Pain Relevance 0.75
It is known that stimulation of the MOR1 leads to the dissociation of the heterotrimeric G?
Positive_regulation (leads) of Positive_regulation (stimulation) of MOR1
2) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0 Pain Relevance 0.56
In contrast to stimulation of MOR1, stimulation of MOR1K leads to increased Ca2+ levels as well as increased nitric oxide (NO) release.
Positive_regulation (leads) of Positive_regulation (stimulation) of MOR1K
3) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link 20525224 Disease Relevance 0.08 Pain Relevance 0
In contrast to stimulation of MOR1, stimulation of MOR1K leads to increased Ca2+ levels as well as increased nitric oxide (NO) release.
Positive_regulation (leads) of Positive_regulation (stimulation) of MOR1
4) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link 20525224 Disease Relevance 0.08 Pain Relevance 0
PHA stimulation increased activation of the MOR promoter as well as levels of MOR mRNA, total receptor protein in cell lysates, and surface and cytoplasmic receptor expression.
Positive_regulation (increased) of Positive_regulation (activation) of MOR associated with mu opioid receptor
5) Confidence 0.45 Published 2005 Journal J. Neurovirol. Section Abstract Doc Link 16036794 Disease Relevance 0.36 Pain Relevance 0.76
In search of proteins regulating the mu-opioid receptor endocytosis, we have recently established that activation of phospholipase D (PLD)2 is required for agonist-induced mu-opioid receptor endocytosis.
Positive_regulation (required) of Positive_regulation (agonist-induced) of mu-opioid receptor associated with agonist and opioid receptor
6) Confidence 0.44 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14720217 Disease Relevance 0 Pain Relevance 0.49
FCS analysis reveals that relevant concentrations of ethanol induce a 3-fold increase in MOP surface density in 10 min.
Positive_regulation (induce) of Positive_regulation (increase) of MOP associated with opioid receptor
7) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2602977 Disease Relevance 0.09 Pain Relevance 0.82
The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor.
Positive_regulation (enhanced) of Positive_regulation (activation) of mu-opioid receptor associated with opioid receptor
8) Confidence 0.32 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10945855 Disease Relevance 0 Pain Relevance 0.67
The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor.
Positive_regulation (important) of Positive_regulation (activation) of mu-opioid receptor associated with opioid receptor
9) Confidence 0.32 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10945855 Disease Relevance 0 Pain Relevance 0.68
This hydrophobic group was designed to mimic the hydrophobic character of the D-Pen residues in DPDPE, which has been found to be extremely important for increasing the binding affinity and selectivity of these non-peptide ligands for the delta-opioid receptor over the mu-opioid receptor.
Positive_regulation (important) of Positive_regulation (increasing) of mu-opioid receptor associated with opioid receptor
10) Confidence 0.32 Published 1998 Journal J. Med. Chem. Section Abstract Doc Link 9822547 Disease Relevance 0 Pain Relevance 0.58
Using transcription factor decoy oligonucleotides, direct evidence was provided that the up-regulation of mu-opioid receptor mRNA in intact cells is dependent on the transcription factors signal transducers and activators of transcription 1 (STAT1) and STAT3, whereas other transcription factors, such as activator protein-1, nuclear factor (NF)-kappaB, or NF-interleukin-6 are not involved.
Positive_regulation (dependent) of Positive_regulation (up-regulation) of mu-opioid receptor mRNA associated with opioid receptor
11) Confidence 0.30 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15448191 Disease Relevance 0.24 Pain Relevance 0.57
The high prevalence of anemia among chronic opioid users leads us to propose that chronic opiate use results in elevated mu opioid receptor levels on human erythrocytes and that these receptor changes may affect erythrocyte membrane properties.
Positive_regulation (results) of Positive_regulation (elevated) of mu opioid receptor in erythrocytes associated with anaemia, mu opioid receptor, opiate and opioid
12) Confidence 0.29 Published 2002 Journal Addict Biol Section Abstract Doc Link 12006216 Disease Relevance 0.18 Pain Relevance 0.63
Thus, sustained activation of the MOP receptor by morphine in sc2 cells seems to promote proteasomal degradation of Gbeta to sensitize adenylate cyclase.
Spec (seems) Positive_regulation (promote) of Positive_regulation (activation) of MOP receptor associated with opioid and morphine
13) Confidence 0.23 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15901846 Disease Relevance 0.20 Pain Relevance 1.09
H2S induces MOR activation and internalization
Positive_regulation (induces) of Positive_regulation (activation) of MOR associated with opioid receptor
14) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0.30 Pain Relevance 0.76
Results from these experiments demonstrate that while MOR activation induced by DAMGO was abrogated by CTAP, the antagonist had no effects on MOR activation induced by Na2S (Figure 6, panel A).
Positive_regulation (induced) of Positive_regulation (activation) of MOR associated with antagonist and opioid receptor
15) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.63
This suggest a hierarchic order in the observed effects with H2S acting as a KATP channels opener leading to activation of PI3K/AKT pathway and MOR activation and phosphorylation (Figure 10).
Positive_regulation (activation) of Positive_regulation (activation) of MOR associated with opioid receptor
16) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.72
receptor-selective enkephalin analog DAMGO and H2S confirm these data demonstrating that, in the neuronal-cell line SKNMC, both DAMGO and H2S induce MOR activation and phosphorylation leading to interaction between MOR and ?
Positive_regulation (leading) of Positive_regulation (activation) of MOR in neuronal associated with opioid receptor and enkephalin
17) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 1.12
By co-immunoprecipitation experiments (Figure 5, panel E) we found that exposure of SKNMCs to DAMGO and Na2S caused a robust induction of MOR association with ?
Positive_regulation (caused) of Positive_regulation (induction) of MOR associated with opioid receptor
18) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.48
Activation of MOR by DAMGO induces AKT phosphorylation [42].
Positive_regulation (induces) of Positive_regulation (Activation) of MOR associated with opioid receptor
19) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.39
We have recently demonstrated that the combination of methadone and morphine enhances the ability of morphine to induce mu-opioid peptide (MOP) receptor endocytosis.
Positive_regulation (enhances) of Positive_regulation (induce) of MOP associated with methadone, opioid and morphine
20) Confidence 0.04 Published 2007 Journal Pharmacology Section Abstract Doc Link 17356311 Disease Relevance 0 Pain Relevance 0.89

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