INT3276

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Context Info
Confidence 0.37
First Reported 1978
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 4.76
Pain Relevance 5.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hypothalamus 1
blood 1
arcuate nucleus 1
brain 1
preoptic area 1
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antinociception 12 100.00 Very High Very High Very High
substance P 2 99.98 Very High Very High Very High
opiate 12 99.92 Very High Very High Very High
ketamine 8 99.74 Very High Very High Very High
Central grey 16 99.64 Very High Very High Very High
antagonist 9 97.98 Very High Very High Very High
midbrain 8 97.20 Very High Very High Very High
medulla 2 97.00 Very High Very High Very High
Opioid 14 96.92 Very High Very High Very High
monoamine 1 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Galactorrhea 10 99.76 Very High Very High Very High
Urological Neuroanatomy 23 99.64 Very High Very High Very High
Schizophrenia 220 98.44 Very High Very High Very High
Nociception 4 98.04 Very High Very High Very High
Weight Loss 2 96.16 Very High Very High Very High
Eating Disorder 5 95.52 Very High Very High Very High
Suicidal Behaviour 2 95.28 Very High Very High Very High
Decapitation 3 95.04 Very High Very High Very High
Diabetes Mellitus 32 94.96 High High
Pain 8 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concentrations of LH were measured in the same experimental models after injection of LH-releasing hormone (LHRH; 1 microgram/kg, i.p.) or saline.
LH-releasing Binding (injection) of
1) Confidence 0.37 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3003224 Disease Relevance 0 Pain Relevance 0.39
It is thought that the ketamine anaesthesia interfered with LH release.
LH Binding (interfered) of associated with ketamine
2) Confidence 0.36 Published 1999 Journal Brain Res. Bull. Section Abstract Doc Link 10372509 Disease Relevance 0.06 Pain Relevance 0.63
The documented association of perifornical LH with the phenomenon of stimulation-induced feeding, and the reciprocal connections between this region and gustatory structures, supports the hypothesis that facilitation of self-stimulation by food restriction is related to the natural phenomenon of positive alliesthesia (i.e. the hunger-dependency of food reward).
LH Binding (association) of associated with eating disorder
3) Confidence 0.36 Published 1993 Journal Brain Res. Section Abstract Doc Link 8481792 Disease Relevance 0.67 Pain Relevance 0.17
Previous studies on the mediobasal hypothalamus (MBH) of rats, rhesus monkeys and goats have detected episodic increases in multiunit activity (MUA volleys) which immediately precede a pulse of luteinizing hormone (LH).
LH Binding (pulse) of in hypothalamus
4) Confidence 0.34 Published 1999 Journal Brain Res. Section Abstract Doc Link 10547003 Disease Relevance 0 Pain Relevance 0.19
In another set of experiments, the specific NK1 receptor antagonist L-703,606 (5 microg) was microinjected in the PAG following LH stimulation with carbachol abolished LH-induced antinociception as well.
LH-induced Binding (antinociception) of associated with antinociception, antagonist and central grey
5) Confidence 0.33 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19356605 Disease Relevance 0.65 Pain Relevance 1.19
Early work demonstrated a putative substance P connection between the LH and the PAG, but the connection is not fully defined.
LH Binding (connection) of associated with central grey and substance p
6) Confidence 0.33 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19356605 Disease Relevance 0.73 Pain Relevance 0.98
Within 2 h after E2 implantation, the frequency of MUA volleys was reduced significantly, probably associated with decreases in the frequency of LH pulses.
LH Binding (associated) of
7) Confidence 0.32 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8022518 Disease Relevance 0 Pain Relevance 0.07
A mechanism by which hyperprolactinemia may change the ability of opiates to influence PRL and LH is by altering the density of opiate receptors.
LH Binding (influence) of associated with galactorrhea and opiate
8) Confidence 0.30 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2559342 Disease Relevance 0.45 Pain Relevance 0.44
There was no consistent effect of any treatment on hypothalamic concentration of pro-LH releasing hormone (RH) (LHRH), LHRH, or on steady-state levels of LHRH mRNA.
LH Neg (no) Binding (concentration) of
9) Confidence 0.27 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756033 Disease Relevance 0.12 Pain Relevance 0.19
These results show that M and T interact to suppress LH and FSH release in the apparent absence of any appreciable effect on hypothalamic monoamines.
LH Binding (interact) of associated with monoamine
10) Confidence 0.26 Published 1988 Journal Brain Res. Section Abstract Doc Link 2454704 Disease Relevance 0 Pain Relevance 0.26
Both blood-collecting methods demonstrated that, in the 3 ages tested, serum T increased with age, LH and FSH decreased with age, and Prl did not change with age, indicating that blood collection by cardiac puncture is as valid a method as is decapitation for assessing serum hormone levels during maturation.
LH Binding (decreased) of in blood associated with decapitation
11) Confidence 0.25 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 687389 Disease Relevance 0.18 Pain Relevance 0.08
These results suggest that the LH and/or the prolactin surge is associated with a significant reduction in the activity of brain areas known to be essential components of the central control of gonadotropin and prolactin secretion.
LH Binding (associated) of in brain
12) Confidence 0.22 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3399035 Disease Relevance 0 Pain Relevance 0.25
We observed that in control rats, NPY concentrations in selected hypothalmic sites (median eminence, medial preoptic area, and arcuate nucleus) increased either just before LH rise at 1400 h or in association with the moderate LH surge in the afternoon.
LH Binding (association) of in preoptic area associated with urological neuroanatomy
13) Confidence 0.21 Published 1990 Journal Endocrinology Section Abstract Doc Link 2404749 Disease Relevance 0.18 Pain Relevance 0.53
activity by rosiglitazone, however, did not significantly alter the concentrations of gonadotropins LH and FSH, sex steroid T (both total serum and intratesticular) or serum E2.
gonadotropins LH Neg (not) Binding (concentrations) of
14) Confidence 0.12 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696180 Disease Relevance 0.79 Pain Relevance 0.04
We observed that in control rats, NPY concentrations in selected hypothalmic sites (median eminence, medial preoptic area, and arcuate nucleus) increased either just before LH rise at 1400 h or in association with the moderate LH surge in the afternoon.
LH Binding (association) of in arcuate nucleus associated with urological neuroanatomy
15) Confidence 0.07 Published 1990 Journal Endocrinology Section Abstract Doc Link 2404749 Disease Relevance 0.18 Pain Relevance 0.53
Although women with schizophrenia treated with conventional and atypical antipsychotic medications have low levels of estrogen and LH due to medication effects on prolactin, the low estrogen and LH are not always associated with hyperprolactinemia.18 In chronic schizophrenia, reductions of basal LH have been reported.149 LH levels in male suicide attempters have been found marginally elevated, but T levels were decreased, and the lowest T levels were in the subgroup with schizophrenia.150
LH Binding (associated) of associated with galactorrhea, suicidal behaviour and schizophrenia
16) Confidence 0.05 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.77 Pain Relevance 0

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