INT32760

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Context Info
Confidence 0.51
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 11
Disease Relevance 6.32
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PTHLH) intracellular (PTHLH) cell-cell signaling (PTHLH)
cytoplasm (PTHLH) extracellular space (PTHLH) extracellular region (PTHLH)
Anatomy Link Frequency
chondrocytes 2
mammary gland 2
smooth muscle 2
MDA-MB-231 2
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 51 100.00 Very High Very High Very High
corticosteroid 2 100.00 Very High Very High Very High
Mechanotransduction 64 97.80 Very High Very High Very High
Opioid 1 91.20 High High
Pain 8 52.84 Quite High
metalloproteinase 9 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 61 100.00 Very High Very High Very High
Cancer 368 99.84 Very High Very High Very High
Hypertension 8 97.76 Very High Very High Very High
Metastasis 184 96.76 Very High Very High Very High
Bone Cancer 48 93.40 High High
Heart Disease 8 92.40 High High
Hypercalcemia 45 90.28 High High
Disease 20 88.68 High High
Galactorrhea 37 88.48 High High
Carcinoma 8 84.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data demonstrating stimulation of PTH-rP in the suckled, but not the contralateral mammary gland provides evidence that a locally produced factor stimulates PTH-rP [49] and there is increasing evidence that extracellular calcium regulates PTHrP production via the calcium receptor in the lactating breast [50].
Regulation (regulates) of Gene_expression (production) of PTHrP in mammary gland
1) Confidence 0.51 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.38 Pain Relevance 0
To test our hypothesis that cytoskeleton-dependent forces regulate PTHrP expression in tumor cells, we designed a 2D tumor cell mono-culture system.
Regulation (regulate) of Gene_expression (expression) of PTHrP associated with cancer
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.92 Pain Relevance 0
Therefore, we hypothesized that the differential rigidity of the bone microenvironment might influence PTHrP expression by tumor cells through mechanically transduced signals.
Spec (might) Regulation (influence) of Gene_expression (expression) of PTHrP associated with cancer
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.77 Pain Relevance 0
Mechanically transduced signals have been shown to regulate PTHrP expression and secretion in a variety of smooth muscle beds [6].
Regulation (regulate) of Gene_expression (expression) of PTHrP in smooth muscle
4) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 1.24 Pain Relevance 0.05
Mechanical signals induced by substrate rigidity regulate the expression of Gli2 and PTHrP though ROCK.
Regulation (regulate) of Gene_expression (expression) of PTHrP
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.97 Pain Relevance 0.04
The effects of substrate modulus on PTHrP gene expression followed a sigmoid curve that saturates between 1.7 and 67GPa, which overlaps with the elastic modulus of bone.
Regulation (effects) of Gene_expression (expression) of PTHrP gene
6) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.37 Pain Relevance 0
To further test the hypothesis that modulus effects on PTHrP expression were mediated by ROCK, we pharmacologically inhibited mechanotransduction in MDA-MB-231 and RWGT2 cells on 2 GPa tissue culture polystyrene substrates with blebbistatin or the ROCK inhibitor, Y27632.
Regulation (effects) of Gene_expression (expression) of PTHrP in MDA-MB-231 associated with mechanotransduction
7) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.06 Pain Relevance 0.12
Taken together, the data in Figure 4 indicate that the effects of substrate modulus on PTHrP gene expression are mediated by ROCK.


Regulation (effects) of Gene_expression (expression) of PTHrP gene
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.08 Pain Relevance 0.06
mediates the effects of substrate rigidity on Gli2 and PTHrP expression through ROCK
Regulation (effects) of Gene_expression (expression) of PTHrP
9) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.08 Pain Relevance 0.03
Furthermore, the expression of PTHrP in chondrocytes obtained from cartilage tissues from patients with osteoarthritis during hip replacement surgery was dependent on the degree of cartilage degeneration.
Regulation (dependent) of Gene_expression (expression) of PTHrP in chondrocytes associated with osteoarthritis
10) Confidence 0.15 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.44 Pain Relevance 0.51
The effects of a single bolus dose of etomidate 0.3 mg kg-1 or thiopentone 5 mg kg-1, on the synthesis of corticosteroid hormones and adrenocorticotrophic hormone (ACTH), were compared for 24 h in 12 patients, undergoing minor surgery under general anaesthesia.
Regulation (effects) of Gene_expression (synthesis) of adrenocorticotrophic hormone associated with corticosteroid
11) Confidence 0.05 Published 1985 Journal Br J Anaesth Section Abstract Doc Link 2982387 Disease Relevance 0 Pain Relevance 0.18

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