INT327666

Context Info Confidence 0.20 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.55

peptidase activity (Adam10) nucleocytoplasmic transport (Adam10) Golgi apparatus (Adam10) nucleus (Adam10) cytoplasm (Adam10)

Adam10 (Mus musculus)

Pain Link Frequency Relevance Heat Catecholamine 8 98.20 gABA 4 80.16 antagonist 4 77.28 dopamine receptor 6 76.84 Ventral tegmentum 4 71.08 Nucleus accumbens 10 70.12 long-term potentiation 2 60.08 addiction 4 40.88 Catechol-O-methyltransferase 54 37.56 Hippocampus 18 29.28

Disease Link Frequency Relevance Heat Sprains And Strains 114 34.36 Neurodegenerative Disease 2 33.12 Cognitive Disorder 12 5.00 Disease 8 5.00 Pain 4 5.00 Aggression 4 5.00 Stress 4 5.00 Dislocations 2 5.00 Schizophrenia 2 5.00 Anxiety Disorder 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Downstream targets of Comt participate in cytoskeletal regulation (Cmip, Etnk1, and Ptprd), intracellular signaling (Cdc42, Araf, Hipk2, Cmip, Etnk1, Ptprd, and Rasgrp1), transport (Stau1, Adam10, Dnajc10, Mcoln1, Golga3, Arl7, Spo, Pitpnb, Ddx47, Capns1, and Kif5a), receptor/channel trafficking (Palm, Akap9, Sqstm1, Cntn2, Nsg1, and Dlgap1), synaptic maintenance and plasticity (Apba1, Tle3, Slit3, Slc12a6, Elavl4, and Syt1), transcriptional regulation (Nipbl, Myt1l, Ncor1, Jundm2, and Tef), and catecholamine metabolism (Maoa).

Regulation (regulation) of Adam10 associated with catecholamine

1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0 Pain Relevance 0.28

Downstream targets of Comt participate in cytoskeletal regulation (Cmip, Etnk1, and Ptprd), intracellular signaling (Cdc42, Araf, Hipk2, Cmip, Etnk1, Ptprd, and Rasgrp1), transport (Stau1, Adam10, Dnajc10, Mcoln1, Golga3, Arl7, Spo, Pitpnb, Ddx47, Capns1, and Kif5a), receptor/channel trafficking (Palm, Akap9, Sqstm1, Cntn2, Nsg1, and Dlgap1), synaptic maintenance and plasticity (Apba1, Tle3, Slit3, Slc12a6, Elavl4, and Syt1), transcriptional regulation (Nipbl, Myt1l, Ncor1, Jundm2, and Tef), and catecholamine metabolism (Maoa).

Regulation (regulation) of Adam10 associated with catecholamine

2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0 Pain Relevance 0.27

General Comments

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