INT327669

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
brain 2
Maoa (Mus musculus)
Pain Link Frequency Relevance Heat
dopamine receptor 3 97.60 Very High Very High Very High
antagonist 2 96.88 Very High Very High Very High
GABAergic 1 87.04 High High
Catecholamine 4 83.96 Quite High
Neurotransmitter 5 77.76 Quite High
gABA 2 73.12 Quite High
Nucleus accumbens 5 66.00 Quite High
Catechol-O-methyltransferase 27 64.64 Quite High
Ventral tegmentum 2 21.08 Low Low
Hippocampus 9 18.24 Low Low
Disease Link Frequency Relevance Heat
Sprains And Strains 57 67.56 Quite High
Disease 4 41.76 Quite Low
Schizophrenia 1 40.40 Quite Low
Eating Disorder 1 39.20 Quite Low
Manic Depressive Disorder 1 37.76 Quite Low
Anxiety Disorder 1 36.32 Quite Low
Drug Dependence 1 35.28 Quite Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, dopaminergic systems are clearly downstream of Comt, including Maoa in the striatum, DRD1 and DRD2 binding density in multiple brain regions, and the response to the dopamine receptor antagonist haloperidol.
Negative_regulation (downstream) of Maoa Binding (binding) of in brain associated with antagonist and dopamine receptor
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.07 Pain Relevance 0.45

General Comments

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