INT327677

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) methyltransferase activity (Comt) plasma membrane (Comt)
Comt (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 34 95.32 Very High Very High Very High
Pain 5 75.36 Quite High
Catecholamine 6 67.88 Quite High
Dopamine 16 64.56 Quite High
Morphine 1 59.28 Quite High
addiction 2 25.32 Quite Low
Nucleus accumbens 5 17.64 Low Low
monoamine 2 12.96 Low Low
Neurotransmitter 5 6.96 Low Low
Hippocampus 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 65 99.36 Very High Very High Very High
Cognitive Disorder 8 87.20 High High
Anxiety Disorder 6 86.64 High High
Stress 3 82.84 Quite High
Pain 5 75.36 Quite High
Aggression 2 58.52 Quite High
Disease 4 43.44 Quite Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low
Schizophrenia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This polymorphism (Comt1B2i; MGI:4819952) was shown to influence Comt1 mRNA abundance, protein levels, enzymatic activity, and behavioral phenotypes.
Regulation (influence) of Transcription (abundance) of Comt1
1) Confidence 0.60 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2958038 Disease Relevance 0.73 Pain Relevance 0.36
In this paper we report the cloning of the cis sequence variant that controls Comt mRNA expression in many inbred strains and that produces widespread effects in the BXD family.
Regulation (controls) of Transcription (expression) of Comt associated with sprains and strains
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.76 Pain Relevance 0.12

General Comments

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