INT327731

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.91
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
lung 2
blood 1
Ltc4s (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 24 69.08 Quite High
cytokine 51 49.84 Quite Low
Inflammatory response 3 23.08 Low Low
chemokine 15 19.04 Low Low
Inflammation 57 16.48 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 42 98.90 Very High Very High Very High
Hypertrophy 3 94.20 High High
Airway Remodeling 78 83.76 Quite High
Severe Combined Immunodeficiency 11 74.56 Quite High
Fibrosis 27 69.08 Quite High
Apoptosis 55 27.56 Quite Low
INFLAMMATION 60 22.72 Low Low
Rhinitis 36 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 3 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic OVA challenge in WT mice induced a significant increase in levels of lung LTC4 compared to non-OVA challenged mice (3.8 ± 0.4 vs 6.6 ± 0.9 ng/ml LTC4)(WT no OVA vs WT OVA)((p < 0.02)(Figure 3D).
Positive_regulation (increase) of LTC4 in lung
1) Confidence 0.24 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0
1+ cells but no increase in LTC4
Neg (no) Positive_regulation (increase) of LTC4
2) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.13 Pain Relevance 0.07
As LTC4 is expressed by eosinophils [19] and has pro-remodeling potential in asthma [20], we examined whether Siglec-F deficient mice had increased levels of lung LTC4 in their remodeled airways.
Spec (whether) Positive_regulation (increased) of LTC4 in lung associated with asthma
3) Confidence 0.16 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.70 Pain Relevance 0
Similar increase in total LTC units was observed with different expanded cord blood units (Figure S2C, n?
Positive_regulation (increase) of LTC in blood
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.07 Pain Relevance 0

General Comments

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