INT327776

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.39
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) cytoplasm (Nqo1)
Nqo1 (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 18 99.78 Very High Very High Very High
Multiple sclerosis 14 99.52 Very High Very High Very High
Spinal cord 11 93.68 High High
addiction 3 90.32 High High
Inflammation 11 86.76 High High
Neuritis 17 56.68 Quite High
Demyelination 4 36.56 Quite Low
cytokine 3 36.16 Quite Low
Dopamine 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 81 100.00 Very High Very High Very High
Demyelinating Disease 30 99.52 Very High Very High Very High
Recurrence 35 90.08 High High
INFLAMMATION 11 86.76 High High
Disease 83 80.60 Quite High
Optic Neuritis 17 56.68 Quite High
Hyperplasia 1 34.40 Quite Low
Hyalinosis 1 33.04 Quite Low
Targeted Disruption 12 31.96 Quite Low
Acute Disease 4 15.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Misu and colleagues [65] conducted an immunohistochemical analysis that revealed loss of AQP4 in 90% of the acute and chronic NMO lesions, which were more pronounced in the active perivascular lesions where immunoglobulins and complements were deposited.
Negative_regulation (loss) of Gene_expression (lesions) of NMO associated with neuromyelitis optica
1) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.55 Pain Relevance 0.28
Unlike in MS, intrathecal total IgG synthesis in NMO does not persist over time [21-24].
Neg (not) Negative_regulation (persist) of Gene_expression (synthesis) of NMO associated with neuromyelitis optica, multiple sclerosis and intrathecal
2) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 0.84 Pain Relevance 0.41

General Comments

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