INT327779

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.50
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AQP4) plasma membrane (AQP4) transmembrane transport (AQP4)
cytoplasm (AQP4)
Anatomy Link Frequency
muscles 4
plasma 2
glial cells 2
brain 2
AQP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 32 98.16 Very High Very High Very High
Inflammation 26 91.20 High High
ischemia 8 88.76 High High
Neurotransmitter 8 83.60 Quite High
Neuritis 26 81.32 Quite High
Central nervous system 4 61.76 Quite High
Spinal cord 41 60.12 Quite High
Substantia nigra 8 48.48 Quite Low
Multiple sclerosis 32 42.80 Quite Low
potassium channel 12 32.08 Quite Low
Disease Link Frequency Relevance Heat
Atrophy 28 99.88 Very High Very High Very High
Motor Neuron Diseases 76 99.42 Very High Very High Very High
Neuromyelitis Optica 252 99.04 Very High Very High Very High
Targeted Disruption 45 99.00 Very High Very High Very High
INFLAMMATION 26 91.20 High High
Stroke 4 89.16 High High
Cv Unclassified Under Development 8 88.76 High High
Pressure And Volume Under Development 1 83.60 Quite High
Disease 290 82.52 Quite High
Neurodegenerative Disease 52 82.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results presented by these authors show a down-regulation of AQP4 expression in striatal glial cells in vitro mediated by DA.
Regulation (regulation) of Gene_expression (expression) of AQP4 in glial cells associated with dopamine
1) Confidence 0.48 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.37 Pain Relevance 0.25
ALS), there has been a very few data on the expression of AQP4; in human muscles with neurogenic atrophy, the expression of AQP4 was down-regulated.
Regulation (regulated) of Gene_expression (expression) of AQP4 in muscles associated with atrophy and motor neuron diseases
2) Confidence 0.35 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.20 Pain Relevance 0.03
ALS), there has been a very few data on the expression of AQP4; in human muscles with neurogenic atrophy, the expression of AQP4 was down-regulated.
Regulation (data) of Gene_expression (expression) of AQP4 in muscles associated with atrophy and motor neuron diseases
3) Confidence 0.35 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.31 Pain Relevance 0.03
A number of recent in vitro and in vivo studies revealed that IgG from patients with NMO initiates endocytosis of AQP4, a process which alters the polarized expression pattern of AQP4 on the plasma membrane and, as a functional consequence, increases BBB permeability in vitro [35-37].
Regulation (alters) of Gene_expression (expression) of AQP4 in plasma associated with neuromyelitis optica
4) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 0.76 Pain Relevance 0.24
The modified AQP4 expression patterns were especially intriguing: changes observed in the expression of ion and water channels could explain the differences in the mobility of water and ions into and out of brain cells and in BBB integrity.
Regulation (modified) of Gene_expression (expression) of AQP4 in brain
5) Confidence 0.21 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.85 Pain Relevance 0.04

General Comments

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