INT327783

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.03
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AQP4) plasma membrane (AQP4) transmembrane transport (AQP4)
cytoplasm (AQP4)
Anatomy Link Frequency
muscles 2
AQP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 10 43.20 Quite Low
Dopamine 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
Neuritis 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 19 99.12 Very High Very High Very High
Atrophy 7 98.12 Very High Very High Very High
Targeted Disruption 11 61.28 Quite High
Respiratory Failure 1 53.00 Quite High
Death 3 51.92 Quite High
Paralysis 3 50.56 Quite High
Muscle Weakness 1 49.64 Quite Low
Disease 69 46.76 Quite Low
Neurodegenerative Disease 13 34.40 Quite Low
Neuromyelitis Optica 57 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study of Jimi and colleagues showed that changes in the levels of AQP4 mRNA in muscles with ALS and other neurogenic atrophies were essentially the same, although there was a greater decrease of AQP4 in ALS than in other neurogenic atrophies.
Regulation (changes) of Transcription (levels) of AQP4 in muscles associated with atrophy and motor neuron diseases
1) Confidence 0.35 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.03 Pain Relevance 0

General Comments

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