INT327785

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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.19
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AQP4) plasma membrane (AQP4) transmembrane transport (AQP4)
cytoplasm (AQP4)
Anatomy Link Frequency
plasma 1
muscles 1
AQP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 18 87.52 High High
addiction 6 85.44 High High
Neuritis 20 77.92 Quite High
Inflammation 16 48.56 Quite Low
Spinal cord 21 42.60 Quite Low
Multiple sclerosis 20 15.68 Low Low
Dopamine 16 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
potassium channel 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 38 99.12 Very High Very High Very High
Atrophy 14 98.12 Very High Very High Very High
Neuromyelitis Optica 138 98.08 Very High Very High Very High
Targeted Disruption 23 86.04 High High
Recurrence 35 78.88 Quite High
Optic Neuritis 20 77.92 Quite High
Demyelinating Disease 44 76.88 Quite High
Respiratory Failure 2 52.40 Quite High
Death 6 51.32 Quite High
Paralysis 6 49.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study of Jimi and colleagues showed that changes in the levels of AQP4 mRNA in muscles with ALS and other neurogenic atrophies were essentially the same, although there was a greater decrease of AQP4 in ALS than in other neurogenic atrophies.
Transcription (levels) of AQP4 in muscles associated with atrophy and motor neuron diseases
1) Confidence 0.56 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.97 Pain Relevance 0
Neither patientsÂ’ nor controls' IgG bound to the HEK-293 cells that were not transfected with the AQP4 containing vector; however, IgG in the sera of NMO patients stained the plasma membrane of AQP4-transfected cells, consistent with the known expression pattern of AQP4 in cells.
Neg (not) Transcription (transfected) of AQP4 in plasma associated with neuromyelitis optica
2) Confidence 0.54 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.99 Pain Relevance 0.04
AQP4-IgG was detected in 21/31 (68%) CSF samples from AQP4-Ab seropositive NMOSD patients. 0/14 CSF samples from AQP4-IgG seronegative NMOSD patients and 0/42 control samples were positive for AQP4-IgG.
Transcription (detected) of AQP4-IgG
3) Confidence 0.48 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 0.23 Pain Relevance 0.19

General Comments

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